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Harmonic
Motion Imaging
Principal
Investigator
Elisa Konofagou, Ph.D.
Students / Research
Scientists
Caroline Maleke
Gary Hou
Thomas Deffieux, Ph.D.
Jonathan Vappou, Ph.D.
Collaborators
Kathie-Ann
P. Joseph, MD, MPH, FACS,
Department of Surgery, Columbia University
Jeffrey A. Ascherman, MD, FACS, Department of Surgery, Columbia
University
Thomas Ludwig, PhD, Department of Pathology, Columbia University
Summary
Palpation
is
routinely used by physicians to distinguish cancerous
tissues from normal tissues in organs such as the breast and the
prostate. This technique is effective because cancerous tissues
typically have higher tissue stiffness characteristic compared to
normal soft tissues. However, the palpation technique is unable to
detect abnormalities deep within tissue, for example, liver. Here, we
introduce the application of the harmonic motion imaging (HMI)
technique that induces dynamic tissue vibrations internally for tissue
elasticity characterization. Moreover, the HMI technique can monitor
changes in tissues elasticity real-time during focused ultrasound
surgery (FUS). Thus, physicians can interrupt the FUS treatment when it
is necessary. The advantages of this technique are detecting cancerous
tissues early and treating them non-invasively.
Support
Whitaker Special Development Award
National Institutes of Health R21 EB008521
Recent Publications
Maleke C. and Konofagou E.E.
Harmonic Motion Imaging for Focused Ultrasound (HMIFU): A Fully
Integrated Technique for Sonication and Monitoring of Thermal Ablation
in Tissues,
Physics in Medicine and Biology 53(6): 1773-1793, 2008.
Maleke, C. and Konofagou E.E.,
Early Tumor Detection and Treatment Guidance in Breast and Liver with
Harmonic Motion Imaging,
International Congress on Ultrasonics, Vienna, Austria, April 2007.
[Invited]
Maleke, C., Pernot, M. and Konofagou E.E.,
A Single-Element Focused Transducer Method for Harmonic Motion Imaging,
Ultrasonic Imaging, 28(3): 144-158, 2006.
Maleke, C. and Konofagou E.E.,
A Harmonic Motion Imaging System for Real-Time Monitoring of
Temperature Changes and Tissue Ablation,
IEEE Proceedings of the Symposium in Ultrasonics, Ferroelectrics and
Frequency Control, Vancouver, Canada, Oct. 2-5, 2006.
Maleke C. and Konofagou E.E.,
An All-Ultrasound System for Sonication and Real-Time Monitoring of
Temperature and Ablation,
IEEE EMBS Symposium in Biomedical Engineering, New York, NY, Aug 30-Sep
3, 2006.
Maleke C. and Konofagou E.,
An Amplitude-Modulated Harmonic Imaging Method for Mapping Tissue
Ablation,
151st Acoustical Society of America Meeting, Providence, RI, June 5-9,
2006.
Maleke, C., Pernot, M. and Konofagou E.E.,
A single transducer for simultaneous generation and monitoring of
thermal treatment,
IEEE Proceedings of the Symposium in Ultrasonics, Ferroelectrics and
Frequency Control, Rotterdam, Netherlands, 17-20, 2005.
Maleke, C., Pernot M. and Konofagou E.E.,
Real-time monitoring of regional tissue elasticity during
High-Intensity Focused Ultrasound therapy using Harmonic Motion Imaging,
International Society of Therapeutic Ultrasound (ISTU), Boston, MA,
USA, Oct. 27-29, 2005.
Maleke C., Pernot M. and Konofagou E.E.
In-vitro demonstration of real time monitoring of regional tissue
elasticity during focused ultrasound therapy using Harmonic Motion
Imaging.
Proceedings of the 4th International Conference on the Ultrasonic
Measurement and Imaging of Tissue Elasticity, October 2005.
Maleke, C., Pernot, M. and Konofagou E.E.,
In-Vitro Demonstration Of Real Time Monitoring Of Regional Tissue
Elasticity During Focused Ultrasound Therapy Using Harmonic Motion
Imaging,
Tissue Elasticity Imaging Conference 2005, Austin, TX, Oct. 17-20, 2005.
Maleke, C., Pernot, M. and Konofagou E.E.,
A single-element focused transducer for simultaneous generation and
monitoring of thermal treatment,
IEEE Proceedings of the Symposium in Ultrasonics, Ferroelectrics and
Frequency Control, Rotterdam, Netherlands, Sept. 17-20, 2005.
Maleke C., Pernot M. Konofagou E.E.
Real-time monitoring of regional tissue elasticity during
High-Intensity Focused Ultrasound therapy using Harmonic Motion Imaging.
Proceedings of the 5th International Symposium on Therapeutic
Ultrasound, Boston, MA, USA 2005. |
