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Myocardial
Elastography
Principal
Investigator
Elisa E. Konofagou, Ph.D.
Students / Research
Scientists
Kana Fujikura, M.D./Ph.D
Wei-Ning Lee, M.S.
Jianwen Luo, Ph.D.
Jean Provost, M.S.
Collaborators
Truman R. Brown, Ph.D., Department of Biomedical Engineering,Columbia
University
Farooq A. Chaudhry, MD, St. Luke’s-Roosevelt Hospital Center,
New York
Kevin D. Costa, Ph.D., Department of Biomedical Engineering, Columbia
University
Jeffrey W. Holmes, M.D., Ph.D., Department of Biomedical Engineering,
University of Virginia
Shunichi Homma, M.D., Department of Medicine, Columbia University
Dimitris N. Metaxas, Ph.D., Department of Biomedical Engineering,
Rutgers University
Ajay Shah, MD, St. Luke’s-Roosevelt Hospital Center, New York
Summary
Early
detection of cardiovascular diseases has been a very active
research area in the field of medical imaging. The objective of this
project is to develop a technique, Myocardial Elastography, for early
detection of cardiovascular disease through measurements of the altered
mechanical properties of the heart muscle. Myocardial Elastography is
designed for measurement of displacement and strain based on natural
contraction of the myocardium.
A theoretical framework has been developed to fundamentally
characterize the performance of Myocardial Elastography and to identify
the optimal parameters to be used for the more reliable detection of
ischemia or infarction. In this simulation study, finite-element (FE)
left-ventricular models serve as gold standards. Our current study
focuses on verifying the Myocardial Elastography technique in a
clinical setting using MRI tagging.
Support
American Heart Association (SDG 0435444T)
National Institutes of Health (R01EB006042)
Wallace H. Coulter Foundation
Recent Publications
Lee, W.-N., Qian, Z., Tosti, C.L., Brown, T.R., Metaxas, D.N.,
Konofagou, E.E.
Preliminary validation of angle-independent myocardial elastography
using MR tagging in a clinical setting, Ultrasound in Medicine and
Biology, 2008, in press.
Wang, S., Lee, W.-N., Provost, J., Luo, J., and Konofagou, E. E.
A composite high-frame-rate system for clinical cardiovascular imaging,
IEEE Trans. Ultrason. Ferroelectr. Freq. Control, Vol. 55, No. 10,
pp.2221-2233, 2008.
Luo J. and Konofagou E.E.
High-Frame Rate, Full-View Myocardial Elastography with Automated
Contour Tracking in Murine Left Ventricles In Vivo,
IEEE Trans. Ultrason. Ferroelectr. Freq. Control, Vol. 55, No. 1,
pp.240-248, 2008.
Lee W.-N., Ingrassia C. M., Fung-Kee-Fung S. D., Costa K. D., Holmes J.
W. and Konofagou E. E.,
Theoretical Quality Assessment of Myocardial Elastography with In Vivo
Validation,
IEEE Trans. Ultrason. Ferroelectr. Freq. Control, Vol. 54, No. 11,
pp.2233-2245, 2007.
Zervantonakis I.K., Fung-Kee-Fung S.D., Lee W-N, and Konofagou E.E.,
A Novel, View-Independent Method For Strain Mapping in Myocardial
Elastography: Eliminating Angle- and Centroid-Dependence,
Physics in Medicine and Biology 52(14): 4063-4080, 2007. |
