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Pulse
Wave Imaging
Principal
Investigator
Elisa E. Konofagou, Ph.D.
Students / Research
Scientists
Jianwen Luo, Ph.D.
Kana Fujikura, M.D.
Jonathan Vappou, Ph.D.
Leslie S. Tyrie, M.D.
Collaborators
M. David Tilson III, M.D., St. Luke's-Roosevelt Hospital Center
Summary
Pulse
waves
are flow velocity, pressure and diameter waves generated by
ventricular ejection. Their propagation speeds and patterns are related
to the vascular mechanical properties (e.g., arterial stiffness).
Because of the limitation of temporal and spatial resolution, the
widely-used foot-to-foot method measures the average value of the
pulse-wave velocity (PWV) between two points with a long distance apart
(>10 cm), instead of the regional value. However, mechanical
properties are nonuniform along the arteries and diseases are typically
regional.
Using a high-resolution (30 MHz) ultrasound system (Vevo 770,
VisualSonics Inc., Toronto, ON, Canada) and a retrospective ECG-gating
technique, radiofrequency (RF) signals of the murine abdominal aorta
have been acquired in vivo at an extremely high frame rate of 8 kHz and
with a full field-of-view (12-mm x 12-mm). The displacements of the
aortic wall over the entire cardiac cycle are estimated using an
RF-based speckle tracking method. The displacement ciné-loop
visually
maps the pulse-wave propagation along the aortic wall (<12 mm)
in
mice. The propagation speeds and patterns of the pulse wave are studied
in normal murine aortas and different models of abdominal aortic
aneurysms (AAAs).
Because of the high temporal and spatial resolution, this
state-of-the-art technique may allow early detection and non-invasive
mapping of vascular diseases, which may decrease mortality among
high-risk patients.
Recent Publications
Luo J, Fujikura K, Tyrie LS, Tilson III MD, Konofagou EE
Pulse wave imaging of normal and aneurysmal abdominal aortas in vivo
IEEE Trans. Med. Imaging 2008; (accepted for publication)
Konofagou EE, Luo J, Lee W-N, Zervantonakis I, Fujikura K, Wang S,
Homma S, Coromilas J.
Mechanical and electromechanical imaging of the cardiovascular system,
presented in Ultrasonic Imaging and Tissue Characterization Symposium
(UITC), May 16-18, 2007, Arlington, VA, USA [Invited].
Fujikura K, Luo J, Konofagou EE, Gamarnik V, Fukumoto R, Pernot M,
Homma S, Tilson III D.
A novel non-invasive technique for pulse-wave imaging and
characterization of vascular mechanical properties in-vivo, presented
in American College of Cardiology (ACC) Annual Scientific Session, Mar
24-27, 2007, New Orleans, LA, USA.
Fujikura K, Luo J, Gamarnik V, Fukumoto R, Tilson III DM, Konofagou EE.
A noninvasive imaging technique for characterization of vascular
mechanical properties in vivo and detection of disease, presented in
American Institute of Ultrasound in Medicine (AIUM) Annual Convention,
March 15-18, 2007, New York, NY, USA
Konofagou EE, Luo J, Fujikura K, Pernot M.
Physiologic wave propagation and characterization in the murine heart
and aorta, presented in Ultrasonic Imaging and Tissue Characterization
Symposium (UITC), May 24-25, 2006, Arlington, VA, USA.
Konofagou E, Fujikura K, Luo J, Pernot M.
Ultrasonic elastography of the mouse aorta: Possible usefulness in
non-invasive analysis of aortic dilation in mice and risk of rupture in
humans, presented in Anniversary Symposium on the Abdominal Aortic
Aneurysm: Genetics, Pathophysiology, and Molecular Biology, April
3–5, 2006, New York, NY, USA [Invited].
Konofagou EE, Luo J, Fujikura K, and Pernot M.
Elastographic imaging of the murine heart and aorta for the detection
of disease at high temporal and spatial resolutions, presented in
International Conference on Ultrasonic Biomedical Microscanning, Sept
10-15, 2006, Corsica, France [Invited].
Fujikura K, Luo J, Gamarnik V, Pernot M, Fukumoto R, Tilson III DM,
Konofagou EE.
A novel, non-invasive technique for pulse-wave imaging and
characterization of clinically significant vascular mechanical
properties in vivo, submitted to Ultrasonic Imaging.
Fujikura K, Luo J, Pernot M, Fukumoto R, Tilson III D, Konofagou EE
Pulse wave imaging in murine abdominal aortas: A feasibility study
Proc. of IEEE Ultrasonics
Symp, 2006, 868-871. |
