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X. Edward Guo

Faculty Photo
X. Edward Guo
Professor of Biomedical Engineering
351 Engineering Terrace
1210 Amsterdam Avenue, Mail Code: 8904

Phone: +1 212-854-6196
Fax: +1 212-854-8725
Email:
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Education

  • 1984: B.S., Applied Mechanics/Biomechanics, Peking University

  • 1990: M.S., Mechanical Engineering/Medical Engineering, Harvard University

  • 1994: Ph.D., Medical Physics/Medical Engineering, Harvard–MIT Division of Health Sciences and Technology
  • 1993-96: Post-doctoral Training in Musculoskeletal Bioengineering, University of Michigan

Research Interests

  • In vivo bone adaptation
  • Age-related fractures
  • Micromechanics and damage mechanics of bone tissue

Publications

  • Guo, X. and Wu, W-Y (1987) The Stokes Flow Produced by An Arbitrary Axisymmetric Oblate Body Moving Perpendicularly Toward An Infinite Flat Wall Along Its Minor Axis, Acta Scientiarum Naturalium Universitatis Pekinensis, 1:39-48.
  • Guo, X. and Wu, W-Y (1988) An Approach to the Mathematical Modeling of the Pulse Condition–The Displacement Wave, (Chinese) Journal of Biomechanics, 3(1):21-26.
  • Guo, X. and Wu, W-Y (1988) The Mathematical and Mechanical Models in Biomechanics of the Spine: Review, Foreign Medicine: Biomedical Engineering (P. R. China), 11(6):296-301.
  • Wu, W-Y, Liang, L. and Guo, X. (1990) The Mixed Finite Element Method for Axisymmetric Stokes Flow on the Unbounded Domains. Chinese Journal of Computational Physics, 7(3):294-302.
  • Guo, X. and Wu, W-Y (1991) Mechanical Analysis of Correction of Scoliosis by Means of Shape Memory Alloy Rods–Simple Mathematical and Mechanical Model, Chinese Journal of Biomedical Engineering, 10(2):87-93.
  • Guo, X. and Cowin, S. (1992) Periosteal and Endosteal Control of Bone Remodeling Under Torsional Loading, J. Biomechanics, 25:645-650.
  • Michel, M. C., Guo, X. E., Gibson, L. J., McMahon, T. A. and Hayes, W. C. (1993) Compressive Fatigue Behavior of Bovine Trabecular Bone, J. Biomechanics, 26:453-463.
  • Guo, X. E., Gibson, L. J., McMahon, T. A., Keaveny, T. M. and Hayes, W. C. (1994) Finite Element Modeling of Damage Accumulation in Trabecular Bone Under Cyclic Loading, J. Biomechanics, 27:145-155.
  • Keaveny, T. M., Guo, X. E., Watchtel, E. F., McMahon, T. A. and Hayes, W. C. (1994) Trabecular Bone Exhibits Fully Linear Elastic Behavior and Yields at Low Strains, J. Biomechanics, 27:1127-1136.
  • Keaveny, T. M., Watchtel, E. F., Guo, X. E. and Hayes, W. C. (1994) The Mechanical Properties of Damaged Trabecular Bone, J. Biomechanics, 27:1309-1318.
  • Gulberg, R. E., Caldwell, N. J., Guo, X. E., Goulet, R. W. and Goldstein, S. A. (1997) Mechanical Stimulation of Tissue Repair in the Hydraulic Bone Chamber, J. Bone Miner. Res., 12:1295-302.
  • Guo, X. E. and Goldstein, S. A. (1997) Is trabecular Bone Tissue Different from Cortical Bone Tissue? Forma, 12:185-196.
  • Guo, X. E., Liang, L. C. and Goldstein, S. A. (1998) Micromechanics of Osteonal Cortical Bone Fracture, J. Biomech. Eng., 120:112-117.
  • Bowman, S. M., Guo, X. E., Cheng, D. W., Keaveny, T. M., Gibson, L. J., Hayes, W. C. and McMahon, T. A. (1998) Creep Contributes to the Fatigue Behavior of Bovine Trabecular Bone, J. Biomech. Eng., 120:647-654.
  • Guo, X. E., and Gibson, L. J. (1999) Behavior of Intact and Damaged Honeycombs: A Finite Element Study, Intl. J. Mech. Eng., 41:85-105.
  • Zysset, P. K., Guo, X. E., Hoffler, C. E., Moore, K. E. and Goldstein S. A. (1998) Mechanical Properties of Human Trabecular Bone Lamellae Quantified by Nanoindentation, Technology and Health Care, 6:429-432.
  • Sun, D. N., Gu, W. Y., Guo, X. E., Lai, W. M. and Mow, V. C. (1999) A Mixed Finite Element Formulation of Triphasic Mechano-Electrochemical Theory for Charged, Hydrated Biological Soft Tissues, Int. J. Num. Methods Eng., 45:1375-1402.
  • Zysset, P. K., Guo, X. E., Hoffler, C. E., Moore, K. E. and Goldstein, S. A. (1999) Elastic Modulus of Human Cortical and Trabecular Tissue Lamella, J. Biomech., 32:1005-1012.
  • Guo, X. E. and Goldstein, S. A. (2000) Vertebral Trabecular Lamellar Modulus Does Not Change in Ovarietomized Rats, J. Orthop. Res., 18:333-336.
  • Schaffner, G., Guo, X. E., Silva, M. J. and Gibson, L. J. (2000) Modeling Fatigue Damage Accumulation in Two-Dimensional Voronoi Honeycombs, Intl. J. Mech. Eng., 42:645-656.
  • Guo, X. E., and Kim, C. H. (2002) Mechanical Consequence of Bone Loss and Treatment in Trabecular Bone: A 3D Microstructural Model, Bone, 30:404-411.
  • Guo, X. E., Eichler, M. J., Takai, E. and Kim, C. H. (2002) A Rat Tail Vertebrae Model for Trabecular Bone Adaptation Studies, J. Biomech. 35:363-368.
  • Lai, W. M., Sun, D. D., Ateshian, G. A., Guo, X. E. and Mow, V. M. (2002) Electrical Signals for Chondrocytes in Cartilage, Biorheology, 39(1/2):11-25.
  • Wang, C. C.-B., Guo, X. E., Sun, D. D., Mow, V. C., Ateshian, G. A., and Hung, C. T. (2002) The Functional Environment of Chondrocytes within Cartilage Subjected to Compressive Loading: Theoretical and Experimental Approach, Biorheology, 39(1/2):39-45.
  • Mow, V. C. and Guo, X. E. (2002) Mechano-Electrochemical Properties of Articular Cartilage: Their Inhomogeneities and Anisotropies, Annual Review in Biomedical Engineering, 4:175-209.
  • Kim, C. H., Takai, E., Zhou, H., von Stechow, D., Müller, R., Dempster, D. W. and Guo, X. E. (2003) Trabecular Bone Response to Mechanical and Parathyroid Hormone Stimulation: The Role of Mechanical Microenvironments, J. Bone and Miner. Res., 18(12):2116-2125.
  • Hung, C. T., Lima, E G., Mauck, R. L., Takai E., LeRoux, M. A., Lu, H. H., Stark, R. G., Guo, X. E., and Ateshian, G. A. (2003) Anatomically Shaped Osteochondral Constructs for Articular Cartilage Repair, J. Biomemch., 36(12):1853-1864.
  • Chua, S. C. Jr., Liu, S. M., Li, Q., Sun, A., DeNino, W. F., Heymsfield, S. B., and Guo, X. E. (2004) Transgenic Complementation of Leptin Receptor Deficiency. II. Increased Leptin Receptor Transgene Dose Effects on Obesity/diabetes and Fertility/lactation in Lepr-db/db Mice, Am. J. Physiol. Endocrinol. Metab., 286(3):E384-392.
  • Sun, D. D., Guo, X. E., Likhitpanichkul, M., Lai, W. M. and Mow, V. C. (2004) The Influence of the Fixed Negative Charges on Mechanical and Electrical Behaviors of Articular Cartilage under Unconfined Compression, ASME J Biomech. Eng., 126:6-16.
  • Lu, L., Sun, D. D. N. Guo, X. E., Chen, F. H., Lai, W. M., and Mow, V. C. (2004) Indentation Determined Mechanoelectrochemical Properties and Fixed Charge Density of Articular Cartilage, Ann. Biomed. Eng., 32(3):370-379.
  • Wan, L. Q., Miller, C., Guo, X. E., and Mow, V. C. (2004) Fixed Electrical Charges and Mobile Ions Affect the Measurable Mechano-Electrochemical Properties of Charged-Hydrated Biological Tissues: The Articular Cartilage Paradigm, Mech. Chem. Biosys., 1(1):81-99.
  • Dong, X. N. and Guo, X. E. (2004) The Dependence of Transversely Isotropic Elasticity of Human femoral Cortical Bone on Porosity, J. Biomech., 37:1281-2187.
  • Taikai, E., Mauck, R. L., Hung, C. T. and Guo, X. E. (2004) Osteocyte Viability and Regulation of Osteoblast Function in a 3D Trabecular Bone Explant under Dynamic Hydrostatic Pressure, Journal of Bone and Mineral Research, 19(9):1403-1410.
  • Dong, X. N. and Guo, X. E. (2004) Geometric Determinants to Cement Line Debonding and Osteonal Lamellae Failure in Osteon Pushout Tests, ASME J. Biomech. Eng., 126(3):387-390.
  • Dong, X. N., Zhang, X. H., Huang, Y. Y., and Guo, X. E. (2005) A Generalized Self-consistent Estimate for the Effective Elastic Moduli of Fiber-reinforced Composite Materials with Multiple Transversely Isotropic Inclusions, Int. J. Mech. Eng., 47:922–940.
  • Takai, E., Costa, K. D., Shaheen, A., Hung, C. T., and Guo, X. E. (2005) Osteoblast Elastic Modulus Measured by Atomic Force Microscopy Is Substrate Dependent, Annals of Biomedical Engineering, 33(7):963–971. (Cover Picture)
  • Dong, X. N., Zhang, X., and Guo, X. E. (2005) Interfacial Strength of Cement Lines in Human Cortical Bone, Mechanics & Chemistry of Biosystems, 2(2):63-68.
  • Lu, H. H., Jiang, J., Tang, A., Hung, C. T., and Guo, X. E. (2005) Development of Controlled Heterogeneityy on a Polymer-Ceramic Hydrogel Scaffold for Osteocondral Repair, Key Engineering Materials, 284-286:607-610.
  • Xu, X. L., Tang, T., Dai, K., Zhu, Z., Guo, X. E., Yu, C., Lou, J. (2005) Immune Response and Effect of Adenovirus-mediated Human BMP-2 Gene Transfer on the Repair of Segmental Tibial Bone Defects in Goats, Acta Orthopaedica, 76(5):637–646.
  • Hoffler, C. E., Guo, X. E., Zysset, P. K., and Goldstein, S. A. (2005) An Application of Nanoindentation Technique to Measure Bone Tissue Lamellae Properties, ASME J. Biomech. Eng., 127(7):1046-1053.
  • Likhitpanichkul, M., Guo, X. E., and Mow, V. C. (2005) Tension-Comprression Nonlinearity Influences the Mechano-Electrochemical Environment of Chondrocytes in Cartilage under Unconfined Compression, Molecular and Cellular Biomechanics, 2(4):191-204.
  • Takai, E., Landersberg, R., Katz, R. W., Hung, C. T. and Guo, X. E. (2006) Osteoblast Cell Adhesion Strength and Focal Adhesion Kinase Activation on Various Substrates, Molecular and Cellular Biomechanics, 3(1):1-12.
  • Dong, X. N., and Guo, X. E. (2006) Prediction of Cortical Bone Stiffness Using a Generalized Self-Consistent Method, ASME Journal of Biomechanical Engineering, 128(3):309-16.
  • Ishii, Y., Thomas, A. O., Lawler, J., Guo, X. E., Ateshian, G. A., Hung, C. T., and Chen, F. H. (2006) Localization and Distribution of Cartilage Oligomeric Matrix Protein in the Rat IVD, Spine, 31(14):1539-46.
  • Ho, M. M., Kelly, T. N., Guo, X. E., Ateshian, G. A., and Hung, C. T. (2006) Spatially Varying Material Properties of the Rat Caudal Intervertebral Disc, Spine, 31(15):E486-93.
  • Liu, X. S., Sajda, P., Saha, P. K., Wehrli, F. W., and Guo, X. E. (2006) Quantification of the Roles of Trabecular Micro-architecture and Trabecular Type in Determining the Elastic Modulus of Human Trabecular Bone, Journal of Bone and Mineral Research, 21(10):1608-1617.
  • Guo, X. E., Takai, E., Jiang, X., Xu, Q., Whitesides, G. M., Yardley, J. T., Hung, C. T., Chow, E. M., and Costa, K. D. (2006) Intracellular Calcium Waves in Bone Cell Networks Under Single Cell Nanoindentation, Molecular & Cellular Biomechanics, 3(3):95-107.
  • Freed, L. E., Guilak, F., Guo, X. E., Gray, M. L., Tranquillo, R., Holmes, J. W., Radisic, M., Sefton, M. V., Kaplan, D., and Vunjak-Novakovic, G. Advanced Tools: Scaffolds, Bioreactors, Signaling, Tissue Engineering. In press, 2006.
  • Lu, X. L., Miller, C., Chen, F. H., Guo, X. E., and Van C. Mow Application of the Generalized Triphasic Correspondence Principle for Simultaneous Determination of the Mechanical Properties and Proteoglycan Content of Articular Cartilage by Indentation, Journal of Biomechanics. In press, 2006.
  • Kim, C. H., X. Henry Zhang, Mikhail, G. von Stechow, D., Müller, R. Han Sung Kim, and Guo, X. E. Effects of Thresholding Techniques on µCT Image Based Finite Element Models of Trabecular Bone, ASME Journal of Biomechanical Engineering. Iin press, 2006.

Presentations (Recent)

  • Erica Takai, Qiaobing Xu, X. Justin Jiang, George M. Whitesides, Kevin D. Costa, James T. Yardley, Clark T. Hung, and X. Edward Guo, Role of Cell Separation Distance on Calcium Signaling in Controlled 2-Dimensional Bone Cell Networks, 52nd Annual Meeting of Orthopaedic Research Society, Lakeside Center, McCormick Place, Chicago, IL, March 19-22, 2006.
  • X. Lux Lu, X. Edward Guo, Chester Miller, and Van C. Mow, Triphasic Indentation of Articular Cartilage: Determination of Both Mechanical Properties and Fixed Charge Density, 52nd Annual Meeting of Orthopaedic Research Society, Lakeside Center, McCormick Place, Chicago, IL, March 19-22, 2006.
  • Mandy Ho, Kenneth Ng, Steve Quinnan, Mark Weidenbaum, Gerard Ateshian, X. Edward Guo, and Clark Hung, Cellular Responses of Tissue Engineered Constructs in A Rat-Tail In Vivo Bioreactor, 52nd Annual Meeting of Orthopaedic Research Society, Lakeside Center, McCormick Place, Chicago, IL, March 19-22, 2006.
  • X. Lux Lu, Chester Miller, X. Edward Guo, and Van C. Mow In Situ Electric Field inside An Indented Articular Cartilage, 52nd Annual Meeting of Orthopaedic Research Society, Lakeside Center, McCormick Place, Chicago, IL, March 19-22, 2006.
  • Leo Q. Wan, Chester Miller, X. Edward Guo, and Van C Mow, Proteoglycan Swelling and Collagen Stratification Determine The Curling Behavior of Articular Cartilage, 52nd Annual Meeting of Orthopaedic Research Society, Lakeside Center, McCormick Place, Chicago, IL, March 19-22, 2006.
  • Mei Lin E. Chan, X. Sherry Liu, Brana Vasilic, Felix W. Wehrli, Maria Benito, Peter J. Snyder, and X. Edward Guo, Mechanical and Three-Dimensional Morphological Changes in Tibial Trabecular Bone of Hypogonadal Patients, 52nd Annual Meeting of Orthopaedic Research Society, Lakeside Center, McCormick Place, Chicago, IL, March 19-22, 2006.
  • Xiaowei Liu, Angela Huang, Paul Sajda, and X. Edward Guo, Simulating 3D Architectural and Mechanical Changes in Human Trabecular Bone During Menopause, 52nd Annual Meeting of Orthopaedic Research Society, Lakeside Center, McCormick Place, Chicago, IL, March 19-22, 2006.
  • Xiaowei Liu, Atul Gupta, Grant Bevill, Paul Sajda, Tony Keaveny, and X. Edward Guo, Micromechanical Analyses of Individual Trabeculae in µCT Based Nonlinear Finite Element Models of Human Vertebral Trabecular Bone, 52nd Annual Meeting of Orthopaedic Research Society, Lakeside Center, McCormick Place, Chicago, IL, March 19-22, 2006.
  • X. Sherry Liu, Paul Sajda, Punam K. Saha, Felix W. Wehrli, and X. Edward Guo, A 3D Morphological Analysis of Trabecular Bone Based on Individual Trabeculae Segmentation, 52nd Annual Meeting of Orthopaedic Research Society, Lakeside Center, McCormick Place, Chicago, IL, March 19-22, 2006.
  • Xiaowei Liu, Angela Huang, Paul Sajda, and X. Edward Guo, Realistic Simulation of 3D Architectural and Mechanical Alterations in Human Trabecular Bone During Menopause, Summer Bioengineering Conference, Amelia Island Plantation, Amelia Island, FL, June 21-25, 2006.
  • Xiaowei Liu, Atul Gupta, Grant Bevill, Paul Sajda, Tony Keaveny, and X. Edward Guo, Micromechanical Analyses Of Human Vertebral Trabecular Bone At Individual Trabeculae Level, Summer Bioengineering Conference, Amelia Island Plantation, Amelia Island, FL, June 21-25, 2006.
  • X. Lux Lu, Chester Miller, X. Edward Guo, and Van C. Mow, Electric Field inside Articular Cartilage, Summer Bioengineering Conference, Amelia Island Plantation, Amelia Island, FL, June 21-25, 2006.
  • X. Lux Lu, Chester Miller, X. Edward Guo, and Van C. Mow, An Algorithm for Triphasic Indentation of Articular Cartilage for Simultaneous Determination of Proteoglycan and Mechanical Property, Summer Bioengineering Conference, Amelia Island Plantation, Amelia Island, FL, June 21-25, 2006.
  • Q. Leo Wan, Janine Boumans, Chester Miller, X. Edward Guo, and Van C. Mow, The Role of the Superficial Layer in the Curling and Residual Stress Behaviors of Articular Cartilage, Summer Bioengineering Conference, Amelia Island Plantation, Amelia Island, FL, June 21-25, 2006.
  • Morakot Likhitpanichkul, Christina C. Chow, X. Edward Guo, and Van C. Mow, Determination of BPVE Coefficients for Agarose Gels at Various Concentrations from Unconfined Compression, Summer Bioengineering Conference, Amelia Island Plantation, Amelia Island, FL, June 21-25, 2006.
  • Q. Leo Wan, Chester Miller, X. Edward Guo, and Van C. Mow An Exact Solution for Charged-Hydrated Biological Tissues under Unconfined Compression: The Triphasic Paradigm, 5th World Congress of Biomechanics, Munich, Germany, July 29–August 4, 2006.
  • Morakot Likhitpanichkul, Q. Leo Wan, X. Edward Guo, and Van C. Mow Determination of Tension-Compression Nonlinear Properties and Fixed Charge Density of Articular Cartilage Using A Triphasic, Conewise Linear Elastic Model, 5th World Congress of Biomechanics, Munich, Germany, July 29–August 4, 2006.
  • X. Lux Lu, Chester Miller, X. Edward Guo, and Van C. Mow, Triphasic Indentation of Articular Cartilage: The Simultaneous Determination of both Mechanical Properties and Fixed Charge Density, 5th World Congress of Biomechanics, Munich, Germany, July 29–August 4, 2006.
  • Erica Takai, Qiaobing Xu, X. Justin Jiang, George M. Whitesides, Kevin D. Costa, James T. Yardley, Clark T. Hung and X. Edward Guo, Bone Cell Network [Ca+2]i Waves: Novel “Neural” Circuitry?, 5th World Congress of Biomechanics, Munich, Germany, July 29–August 4, 2006.
  • Xiaowei Liu, Angela Huang, Paul Sajda, and X. Edward Guo, Simulation of 3D Architectural and Mechanical Changes in Human Trabecular Bone During Menopause, 5th World Congress of Biomechanics, Munich, Germany, July 29–August 4, 2006.
  • X. Edward Guo, Xiaowei Liu, and Paul Sajda, Simulation of 3D Architectural and Mechanical Changes in Human Trabecular Bone During Menopause, Annual Meeting of Biomedical Engineering Society, Chicago, IL, October 11-15, 2006.
  • X. H. Zhang, X. Sherry Liu, B. Vasilic, B, F. W. Wehrli, M. Benito, P. J. Snyder, and X. Edward Guo, In Vivo µMRI Based Finite Element Analyses Detected the Restoration of Mechanical Properties of Tibial Trabecular Bone in Hypogonadal Men after Testosterone Treatment, the 53rd Annual Meeting of the Orthopaedic Research Society, San Diego, CA, February 11-14, 2007.
  • Xiaowei S. Liu, Paul Sajda, and X. Edward Guo, Simulating Microstructural and Mineralization Changes during the Treatment of Postmenopausal Osteoporosis by Bisphosphonate, the 53rd Annual Meeting of the Orthopaedic Research Society, San Diego, CA, February 11-14, 2007.
  • X. H. Zhang, X. Sherry Liu, Punam K. Saha, Felix W. Wehrli, and X. Edward Guo, Roles of Trabecular Rods in Determining Elastic Moduli of Human Vertebral Trabecular Bone, the 53rd Annual Meeting of the Orthopaedic Research Society, San Diego, CA, February 11-14, 2007.
  • W. L. Grayson, S. Bhumiratana, P.-H. G. Chao, C. Cannizzaro, X. S. Liu, X. Edward Guo, A. Caplan, and G. Vunjak-Novakovic, Increased Perfusion Rate and Cell Seeding Density Enhance Tissue Engineering of Human Bone, the 53rd Annual Meeting of the Orthopaedic Research Society, San Diego, CA, February 11-14, 2007.

Bone mechanics, bone adaptation to mechanical loads and its cellular/molecular mechanisms, computational modeling of biological tissues, cellular biomechanics, imaging analysis of bone microstructure, micropatterning of cells.