<-- Return to the previous page

Samuel K. Sia

Faculty Photo
Samuel K. Sia
Assistant Professor of Biomedical Engineering
351 Engineering Terrace
1210 Amsterdam Avenue, Mail Code: 8904

Phone: +1 212-854-7549
Fax: +1 212-854-8725
Email:
Home Page


Education

  • 1997: B.Sc. Biochemistry, University of Alberta

  • 2002: Ph.D. Biophysics, Harvard University

  • 2002-5: Postdoctoral Fellow, Chemistry and Chemical Biology, Harvard University

Professional Experience

  • 2005-present: Assistant Professor of Biomedical Engineering, Columbia University

Teaching

  • BMEN 4210 (Fall) - Thermodyanmics of Biological Systems
  • BMEN 3810 (Spring) - Biomedical Engineering Lab I

Honors and Awards

  • 1993-97: Canada Scholar
  • 1997: Dean's Silver Medal in Science, University of Alberta
  • 1997-99: National Science and Engineering Council of Canada Postgraduate Scholarship A
  • 1999-2001: National Science and Engineering Research Council of Canada Postgraduate Scholarship B

  • 1997-2002: Howard Hughes Medical Institute Predoctoral Fellowship

  • 2002: Delegate, International Achievement Summit, Dublin, Ireland
  • 2002: Harvard University Certificate of Distinction in Teaching

  • 2004-5: Canadian Institutes of Health Research Fellowship
  • 2006 American Heart Association Scientist Development Grant
  • 2006 Walter H. Coulter Early Career Award
  • 2007 National Academy of Engineering Frontiers Symposium
  • 2008 NSF CAREER Award
  • 2008 Walter H. Coulter Early Career Award, Phase II

Publications

  • B. M. Gillette, J. A. Jensen, B. Tang, G. J. Yang, A. Bazargan-Lari, M. Zhong and S. K. Sia, "In situ collagen assembly for integrating microfabricated three-dimensional cell-seeded matrices", 7, 636 - 640, Nature Materials. (2008).  [This article was chosen as the cover article, and accompanied by a News & Views article.]
  • J. Lii, W.J. Hsu, H. Parsa, A. Das, R. Rouse and S.K. Sia, "Real-Time Microfluidic System for Studying Mammalian Cells in 3D Microenvironments", 80 (10), 3640–3647, Anal. Chem. (2008). [This article was covered in Chemical and Engineering News. ]
  • C.D. Chin, K. Khanna and S.K. Sia, "A microfabricated porous collagen-based scaffold as prototype for skin substitutes", 10, 459-67, Biomed. Microdev.  (2008).
  • S.K. Sia, B.M. Gillette and G.J. Yang, "Synthetic tissue biology: tissue engineering meets synthetic biology", 81, 354-61, Embryo Today (2007).
  • Y.K. Cheung, B.M. Gillette, M. Zhong, S. Ramcharan and S.K. Sia, "Direct patterning of composite biocompatible microstructures using microfluidics", Lab on a Chip, 7, 574-579 (2007).
  • S.K. Sia, "Developing diagnostics", Chemical Technology (2007).
  • C.D. Chin, V. Linder and S.K. Sia, "Lab-on-a-chip devices for global health", Lab on a Chip, 7, 41-57 (2007).  [This work was chosen as the cover article.] 
  • N. Damean, S.K. Sia, V. Linder, M. Navrolyansky and G.M. Whitesides, "Space- and time-resolved spectrophotometry at the microscale," Proc. Natl. Acad. Sci., 102:10035-9 (2005).
  • D. Weibel, M. Kruithof, S. Potenta, S.K. Sia, A. Lee and G.M. Whitesides,"Torque-actuated valves in microfluidic systems," Anal. Chem., 77:4726-33 (2005).
  • V. Linder, S.K. Sia and G.M. Whitesides, "Reagent-loaded cartridges forvalveless and automated fluid delivery in microfluidic devices," Anal. Chem., 77:64-71 (2005).
  • D. Ryan, B. Amir Parviz, V. Linder, V. Semetey, S.K. Sia, J. Su, M. Mrksichand, G.M. Whitesides, "Patterning multiple aligned self-assembled monolayersusing light," Langmuir, 20:9080-9088 (2004).
  • S.K. Sia, V. Linder, B.A. Parviz, A. Siegel and G.M. Whitesides, "Aportable and low-cost immunoassay for resource-poor settings," Angew. Chemie. Int. Ed., 43:498-502 (2004).  [This work was featured in Science (303:593, 2004), BBC, and Science News.]
  • S.K. Sia and G.M. Whitesides, "Microfluidic devices based onpoly(dimethylsiloxane) for biological studies," Electrophoresis, 24:3563-3576 (2003).
  • S.K. Sia and P.S. Kim, "Protein grafting of an HIV-1 inhibiting epitope," Proc. Natl. Acad. Sci. USA, 100:9756-9761 (2003).
  • S.K. Sia, P.A. Carr, A.G. Cochran and P.S. Kim, "Mechanism of short,constrained a-helical peptides that inhibit HIV-1 entry," Proc. Natl. Acad. Sci. USA, 99:14664-14669 (2002).
  • S.K. Sia and P.S. Kim, "A designed protein featuring packing left andright-handed helices," Biochemistry, 40:8981-8989 (2001).
  • S.K. Sia, M.X. Li, L. Spyracopoulos, S.M. Gagne, W. Liu, J.A. Putkey and B.D. Sykes, "Structure of cardiac troponin C unexpectedly reveals a closedregulatory domain," J. Biol. Chem., 272:18216-18221 (1997). This work was featured as research news in Nature Biotechnology, Sept 1997 (issue 15, p. 826).
  • L. Spyracopoulos, M.X. Li, S.K. Sia, S.M. Gagne, M. Chandra, R.J. Solaroand, B.D. Sykes, "Ca2+-induced structural transition in the regulatorydomain of human cardiac troponin C," Biochemistry, 36:12138-12146 (1997).
  • S.M. Mosimann, M. Chernaia, S.K. Sia, S. Plotch and M.N.G. James, "Therefined X-ray structure of poliovirus 3C protease at 2.0 Å resolution," J. Mol. Biol., 273:1032-1047 (1997).
  • D.M. Pinto, E.A. Arriaga, S. Sia, Z. Li and N.J. Dovichi, "Solid-phasefluorescent labeling reaction of picomole amounts of insulin in very dilutesolutions and their analysis by capillary electrophoresis," Electrophoresis, 16:534-540 (1995).

 

 

Research Interests: 1) Microfabrication to control tissue formation in controlled 3D microenvironments 2) MEMS devices for improving the health of people in developing countries