Laboratory for Stem Cells and Tissue Research
Publications (Page Title)

Peer Reviewed Articles: Before 2000

1999

  1.   56. Obradovic B, Carrier R.L., Vunjak-Novakovic G.V., Freed L.E. Oxygen is essential for Bioreactor Cultivation of Tissue Engineered Cartilage. Biotechnology and Bioengineering 63: 197-205, 1999.
  2.   57. Vunjak-Novakovic G., Martin I., Obradovic B., Treppo S, Grodzinsky A.J., Langer R., Freed L. Bioreactor Cultivation Conditions modulate the Composition and Mechanical Properties of Tissue Engineered Cartilage Journal of Orthopedic Research 17: 130-138, 1999.
  3.   58. Vunjak-Novakovic G., Preda C., Bordonaro J., Pellis N., de Luis J. and Freed L.E. Microgravity Studies of Cells and Tissues: from Mir to ISS, American Institute of Physics 1: 442-452, 1999. Article presented in “Microgravity Abstracts”, Japan Space Utilization Promotion Center (JSUP), Tokyo Japan (with permission)
  4.   59. Freed L.E., Pellis N., Searby N., de Luis J., Preda C., Bordonaro J., Vunjak- Novakovic G. Microgravity Cultivation of Cells and Tissues. Gravitational and Space Biology Bulletin 12: 57-66, 1999.
  5.   60. Freed L.E., Martin I., Vunjak-Novakovic G. Frontiers in Tissue Engineering: in vitro Modulation of Chondrogenesis, Clinical Orthopedics and Related Research 367S: S46-S58, 1999.
  6.   61. Carrier R., Papadaki M., Rupnick, M., Schoen F.J. , Bursac N., Langer R., Freed L.E, Vunjak-Novakovic G. Cardiac Tissue Engineering: Cell Seeding, Cultivation Parameters and Tissue Construct Characterization, Biotechnology and Bioengineering  64: 580-589, 1999.
  7.   62. Bursac N., Papadaki M., Cohen R.J., Schoen F.J., Eisenberg S.R., Carrier R., Vunjak-Novakovic G., Freed L.E. Cardiac Muscle Tissue Engineering: Towards an in vitro Model for Electrophysiological Studies. American Journal of Physiology 277 (Heart Circ. Physiol. 46): H433-H444, 1999.
  8.   63. Martin I., Obradovic B., Freed L.E., Vunjak-Novakovic G. A Method for Quantitative Analysis of Glycosaminoglycan Distribution in Cultured Natural and Engineered Cartilage. Annals of Biomedical Engineering 27 (5) 1-7, 1999.
  9.   64. Martin, I., Vunjak-Novakovic, G, Yang, J., Langer, R., Freed, L.E. Mammalian Chondrocytes Expanded in the Presence of Fibroblast Growth Factor-2 Maintain the Ability to Differentiate and Regenerate Three-Dimensional Cartilaginous Tissue. Experimental Cell Research 253: 681-688, 1999.

1998

  1.   49. Vunjak-Novakovic G., Obradovic B., Bursac P., Martin, I., Langer R. Freed L.E. Dynamic Seeding of Polymer Scaffolds for Cartilage Tissue Engineering, Biotechnology Progress 14: 193-202, 1998.
  2.   50. Searby, N.D, de Luis, J., Vunjak-Novakovic, G. Design and Development Testing of a Space Station Cell Culture Unit”, SAE Transactions – Journal of Aerospace, pp. 1-13, 1998.
  3.   51. Martin, I, Padera, R.F., Vunjak-Novakovic, G., Freed, L.E. In Vitro Differentiation of Chick Embryo Bone Marrow Stromal Cells into Cartilaginous and Bone-like Tissues, Journal of Orthopedic Research 16: 181-189, 1998.
  4.   52. Freed, L.E., Hollander, A.P., Martin, I., Barry, J.R., Martin, I., Vunjak-Novakovic, G. Chondrogenesis in a Cell-Polymer-Bioreactor System, Experimental Cell Research 240: 58-65, 1998.
  5.   53. Riesle J., Hollander A.P., Langer R., Freed L.E. and Vunjak-Novakovic G. Collagen in Tissue Engineered Cartilage: Types, Structure and Crosslinks. Journal of Cellular Biochemistry 71: 313-327 1998.
  6.   54. Freed, L.E., Vunjak-Novakovic, G., Culture of Organized Cell Communities, Advanced Drug Delivery Reviews 33 (1, 2) 15-30 1998.
  7.   55. Vunjak-Novakovic G., Vunjak N., Kundakovic Lj., Obradovic B., Nedovic V., Sajc L. and Bugarski B. Air-lift reactors: research and applications. Trends in Chemical Engineering 5: 159-172, 1998.

1997

  1.   44. Freed, L.E. and G. Vunjak-Novakovic, Microgravity tissue engineering, In Vitro Cellular and Developmental Biology 33: 381-385, 1997.
  2.   45. Vunjak-Novakovic, G., Freed, L.E. Cell polymer bioreactor system for tissue engineering, Journal of the Serbian Chemical Society 62: 787-799, 1997.
  3.   46. Obradovic B, Dudukovic A, Vunjak-Novakovic G. Response Data Analysis of a Three-Phase Airlift Reactor, Transactions of the Institute of Chemical Engineers 75 (A) 1997.\
  4.   47. Nedovic, V.A., Leskosek-Cukalovic, I., Vunjak-Novakovic, G. Short-Time Fermentation of Beer in an Immobilized Yeast Air-Lift Bioreactor. Journal of the Institute of Brewing 103:65 1997.
  5.   48. Freed, L.E., Langer, R., Martin, I., Pellis, N., Vunjak-Novakovic, G. Tissue engineering of cartilage in space, Proceedings of the National Academy of Sciences USA, Vol. 94: 13885-13890, 1997; commentary in same issue on pp. 13380-13382.

1996

  1.   34. Vunjak-Novakovic, G., L.E. Freed, R.J. Biron and R. Langer, Effects of Mixing on Tissue Engineered Cartilage, Journal of the American Institute of Chemical Engineers 42 (3) 850-860, 1996.

  2.   35. Vunjak-Novakovic G. and L.E. Freed, Cell-Polymer System for Tissue Engineering, Chemical Industry 49 (12) 511-519, 1996.
  3.   36. Bugarski B., N. Vunjak, L. Sajc, Lj. Kundakovic, B. Obradovic, I. Pajic, J. Jelenkovic, Lj. Mojovic, G. Jovanovic and G. Vunjak-Novakovic, Airlift Bioreactors: Fundamental and Developmental Studies, Chemical Industry 49 (12) 520-530, 1996.
  4.   37. Bugarski B., V. Davinic, L. Sajc, M. Plavsic, M.F.A. Goosen, G. Jovanovic, G. Vunjak-Novakovic and P. Djordjevic, Semipermeable Alginate-PLO Microcapsules as a Bioartificial Pancreas, Chemical Industry 49 (12) 531-534, 1996.
  5.   38. Kundakovic Lj., B. Obradovic and G. Vunjak-Novakovic, Fluid Dynamic Studies of a Three-Phase Fluidized Bed, Journal of the Serbian Chemical Society 61 (4-5) 297-310, 1996.
  6.   39. Sajc L., Z. Jovanovic, G. Jovanovic, B. Bugarski and G. Vunjak-Novakovic, The Interfacial Stability of Magnetically Stabilized Fluidized Beds, Journal of the Serbian Chemical Society 61 (4-5) 319-329, 1996.
  7.   40. Freed L.E. and G. Vunjak-Novakovic, Biomedical Reactors: Mixing patterns in oscillating and rotating vessels, Journal of the Serbian Chemical Society 61 (4-5) 283-295, 1996.
  8.   41. Jovanovic Z., G. Jovanovic and G. Vunjak-Novakovic, Bubble Properties in Gas-Solid Magnetically Stabilized Fluidized Beds, Journal of the Serbian Chemical Society 61 (4-5) 267-282, 1996.
  9.   42. Bursac P.M., L.E. Freed, R.J. Biron and G. Vunjak-Novakovic, Mass Transfer Studies of Tissue Engineered Cartilage, Tissue Engineering 2 (2) 141-150, 1996.
  10.   43. Vunjak-Novakovic G., L.E. Freed and R. Langer, Chondrocytes Cultured on Biodegradable Polymers, Synovial Journal de Rhumatologie 4, 4-5, 1996.

1995

  1.   27. Sajc L., G. Vunjak-Novakovic , D. Grubisic, N. Kovacevic, D.V. Vukovic and B. Bugarski, Production of Antraquinons by Immobilized Frangula Alnus Mill. Plant Cells in a Four Phase Air Lift Bioreactor, Applied Microbiology and Biotechnology 43, 416-423, 1995.
  2.   28. Sajc L., B. Obradovic, D.V. Vukovic, B. Bugarski and G. Vunjak-Novakovic, Hydrodynamics and Mass Transfer in a Four Phase External Loop Air Lift Bioreactor, Biotechnology Progress 11, 420-428, 1995.
  3.   29. Langer, R., J.P. Vacanti, C. Vacanti, A. Atala, L.E. Freed and G. Vunjak-Novakovic, Tissue Engineering: Biomedical Applications, Tissue Engineering 1 (2) 151-161, 1995.
  4.   30. Freed L.E. and G. Vunjak-Novakovic, Cultivation of Cell-Polymer Constructs in Simulated Microgravity, Biotechnology and Bioenginneering 46, 306-313, 1995.
  5.   31. Kundakovic Lj. and G. Vunjak-Novakovic, Mechanics of Particle Motion in Three-Phase Flow, Chemical Engineering Science 50 (20) 3285-3295, 1995.
  6.   32. Kundakovic Lj. and G. Vunjak-Novakovic, A Fluid Dynamic Model of the Draft Tube Gas-Liquid-Solid Fluidized Bed, Chemical Engineering Science 50 (23) 3763-3775, 1995.
  7.   33. Sajc, L., G. Jovanovic Z. Jovanovic, B. Bugarski, J. Vukovic and G. Vunjak-Novakovic, Liquid Dispersion in a Magnetically Stabilized Fluidized Bed (MSFB), Mixed-Flow Hydrodynamics, Advances in Engineering Fluid Mechanics Series, pp. 713-740, 1995.

1994

  1.   17. Sajc, L.M., Z.R. Jovanovic, G. Vunjak-Novakovic, G. Jovanovic, R.D. Pesic and D.V. Vukovic, Liquid Dispersion in a Magnetically Stabilized Fluidized Bed (MSFB), Transactions of the Institute of Chemical Engineers 72A, 236-240, 1994.
  2.   18. Bugarski B., Q. Li, M.F.A. Goosen, D. Poncelet, R. Neufeld G. Vunjak-Novakovic, Electrostatic Droplet Generation: Mechanism of Polymer Droplet Formation, Journal of the American Institute of Chemical Engineers 40 (6) 913-1092, 1994.
  3.   19. Obradovic B., A. Dudukovic and G. Vunjak-Novakovic, Local and Overall Mixing Characteristics of the Gas-Liquid-Solid Air-Lift Reactor, Industrial and Engineering Chemistry Research 33, 698-702, 1994.
  4.   20. Freed, L.E., G. Vunjak-Novakovic, R. Biron, D. Eagles, D. Lesnoy, S. Barlow and R. Langer, Biodegradable Polymer Scaffolds for Tissue Engineering, Bio/Technology (precursor of Nature Biotechnology) 12, 689-693, 1994.
  5.   21. Mojovic Lj., S. Siler-Marinkovic, G. Kukic, B. Bugarski and G. Vunjak-Novakovic, Rhizopus Arrhizus Lipase Catalyzed Interesterification of Palm Oil in a Gas-Lift Reactor, Enzyme and Microbial Technology 16, 159-162, 1994.
  6.   22. Freed, L.E., J.C. Marquis, G. Vunjak-Novakovic, J. Emmanual, and R. Langer, Composition of Cell-Polymer Cartilage Implants, Biotechnology and Bioengineering 43, 605-614, 1994.
  7.   23. Freed, L.E., G. Vunjak-Novakovic, J.C. Marquis, and R. Langer, Kinetics of Chondrocyte Growth in Cell-Polymer Implants, Biotechnology and Bioengineering 43, 597-604, 1994.
  8.   24. Sajc L., B. Bugarski, D.V. Vukovic and Vunjak-Novakovic, Four-Phase Air-Lift Bioreactor with Immobilized Plant Cells: Hydrodynamics and Mass Transfer, Biotechnology 8, 30-41, 1994.
  9.   25. Sajc L., B. Bugarski, D.V. Vukovic, G. Vunjak-Novakovic and J. Vukovic, Four-Phase Air-lift bioreactor with Immobilized Plant Cells: Simultaneous Biosynthesis and Extraction of Plant Cell Metabolites, Biotechnology 8, 30-41, 1994.
  10.   26. Sajc L., B. Bugarski D.V. Vukovic, G. Vunjak-Novakovic, J. Vukovic, N. Kovacevic and D. Grubisic, Four-Phase Air-lift Bioreactor with Immobilized Plant Cells: Kinetics of Cell Growth and Product Synthesis, Biotechnology   9-10, 26-33, 1994.

1993 and Earlier

  1.     1. Vukovic, D.V., F.K. Zdanski, G.V. Vunjak, Z.B. Grbavcic and H. Littman. Pressure Drop, Bed Expansion and Liquid Hold-up in a 3-Phase Spouted Bed Contactor. Canadian Journal of Chemical Engineering 52 (2) 180-185, 1974.
  2.     2. Vunjak-Novakovic, G.V. and G. Jovanovic, Principles of Bioreactors Design, in Biotechnology and Genetic Engineering, pp. 19- 23. 1985.
  3.     3. Vunjak-Novakovic G., D.V. Vukovic and H. Littman, Hydrodynamics of Turbulent Bed Contactors: Operating Regimes and Liquid Hold up, Industrial and Engineering Chemistry Research  26 (5) 958-968, 1987.\
  4.     4. Vunjak-Novakovic G., D.V. Vukovic and H. Littman. Hydrodynamics of Turbulent    Bed Contactors: Pressure Drop, Bed Expansion and Minimum Fluidizing Velocity, Industrial and Engineering Chemistry Research 26 (5) 969-974, 1987.
  5.     5. Freed, L.E., G. Vunjak-Novakovic, P.A. Drinker and R. Langer, A Novel Bioreactor Based on Suspended Particles of Agarose-Immobilized Species, Journal of the American Society for Artificial Internal Organs 34, 732-738, 1988.
  6.     6. Vunjak-Novakovic, G., L.E. Freed, S. Ayyadurai, C.L. Cooney and R. Langer, Computer-Aided Visualization and Analysis of Fluid and Particle Motion in Multiphase Systems, Chemical and Biochemical Engineering Quarterly 2, 249-252, 1988.
  7.     7. Bugarski B., G. King, G.  Jovanovic, A. Daugulis, M.F.A. Goosen, and G. Vunjak- Novakovic, “Design and Operation of an Air-Lift Reactor for Production of Monoclonal Antibodies by Immobilized Hybridoma Cells, Periodicum Biologorum 92 (1) 121-123, 1990.
  8.     8. Vunjak-Novakovic G., G. Jovanovic, D.V. Vukovic, N. Vunjak, I.  Pajic and J. Jelenkovic, Fluid-Dynamic Study of the Fluidized Bed Bioreactor with an Internal Draft Tube, Technology Today 4, 216-221, 1991.
  9.     9. Vunjak-Novakovic G., G. Jovanovic, Lj. Kundakovic and B. Obradovic, Flow Regimes and Liquid Mixing in a Draft Tube Gas-Liquid-Solid Fluidized Bed, Chemical Engineering Science, 47 (13-14), 3451-3458, 1992.
  10.   10. Bugarski B., N. Vunjak, G. Jovanovic, K. Cuperlovic and G. Vunjak-Novakovic, Oxygen Mass Transfer in an Air-Lift Bioreactor, Journal of the Serbian Chemical Society, 57 (5-6), 345-352, 1992.
  11.   11. Sajc, L., Z. Jovanovic, G. Jovanovic, G. Vunjak-Novakovic, Lj. Kundakovic, B. Obradovic and D.V. Vukovic, Flow Behavior of Fluidized Beds in a Magnetic Field, Journal of the Serbian Chemical Society, 57 (5-6), 297-308, 1992.
  12.   12. Pajic I., J. Jelenkovic-Bulovic, M. Misic-Vukovic, D.V. Vukovic, G. Jovanovic, and G. Vunjak-Novakovic, Deacylation of Penicillin G by Immobilized Penicillin Acylase; Experimental and Modeling Studies, Journal of the Serbian Chemical Society, 57 (5-6), 365-374, 1992.
  13.   13. Freed, L.E., G. Vunjak-Novakovic and R. Langer, Cultivation of Cell-Polymer Cartilage Implants in Bioreactors, Journal of Cell Biochemistry 51, 257-264, 1993.
  14.   14. Freed, L.E., G. Vunjak-Novakovic, P.A. Drinker and R. Langer, A Bioreactor Based on Suspended Particles of Immobilized Enzyme, Annals of Biomedical Engineering  21, 57-65, 1993.
  15.   15. Freed, L.E., G. Vunjak-Novakovic, H. Bernstein, C.L. Cooney and R. Langer, The Kinetics of Immobilized Heparinase in Human Blood, Annals of Biomedical Engineering 21, 67-76, 1993.
  16.   16. Mojovic Lj., S. Siler, G. Kukic and G. Vunjak-Novakovic, Rhizopus Arrhizus Lipase Catalyzed Interesterification of the Mid Fraction of Palm Oil, Enzyme and Microbial Technology  15 (1) 1-6, 1993