Elizabeth M. C. Hillman, Columbia University

Assistant Professor of Biomedical Engineering

Elizabeth M C Hillman
Columbia University
Department of Biomedical Engineering
351L Engineering Terrace
1210 Amsterdam Ave
New York, NY 10027

Phone: 212 854 2788
Fax: 212 854 8725

eh2245@columbia.edu

Education

1998: MSci (BSc + MSc)., Physics, University College London, London, UK
2002: PhD., Medical Physics and Bioengine ering, University College London, London, U.K.

Professional Experience

2002-2003: Manager of In-vivo Spectroscopy, Argose Inc., Waltham, MA
2005-2006: Assistant Physicist, Department of Radiology, Masachusetts General Hospital, Boston, MA
2005-2006: Instructor in Radiology, Harvard Medical School, Boston, MA
2006-: Assistant Professor, Biomedical Engineering and Radiology, Columbia University, New York, NY.
2006-: Assistant Professor, Department of Radiology, Columbia Presbyterian, New York, NY.

Research Experience

1997: Summer Research Assistant, High Energy Particle Physics Group, University College London
1998-2002: Graduate Student, Biomedical Optics Research Lab, Department of Medical Physics and Bioengineering, University College London, London, UK
2003-2005: Post-doctoral Research Fellow, Martinos Center for Biomedical Imaging (Radiology), Massachusetts General Hospital, Boston, MA.

Professional Affiliations

Optical Society of America (OSA)
The International Society for Optical Engineering (SPIE)
Society for Neuroscience (SFN)
International Society for Cerebral Blood Flow and Metabolism (ISCBFM)

Honors and Awards

Wellcome Trust Prize Studentship, PhD Fellowship (1998-2002).
Outstanding Short Paper award, Rank Prize Fund Mini-symposium on applications of fast low-level light detection, Grasmere, UK (2000)
Poster award, Gordon Research Conference: Lasers in Medicine and Biology 2000
Travel Awards for: OSA BIOMED 2000, 2006, Gordon Conference LMB 2000, SPIE Photonics West 2001, Gordon Conference (Brain blood flow and metabolism) 2004, Brain'05 2005.
Program Committee, SPIE Optics East 2005 & 2006 Optical Methods in Drug Discovery and Development
Session Chair (Optics in Neuroscience) and Program Committee Member for National Institute of Health Fifth Inter-Institute Workshop on Optical Diagnostic Imaging from Bench to Bedside, 2006
Session Chair (Imaging brain function and disease), Lasers in Medicine and Biology Gordon Conference 2006)
NIH / NIBIB Study Section Reviewer, ZEB1 OSR-A M1 S: “New Ways to Image Neural Activity”
NIH Study Section reviewer: ZRG1 BST-M (50) R: "Nanotechnology" 2007
NIH Study Section reviewer: BMIT: "Biomedical Imaging Technology" 2007
Wallace H. Coulter Early Career Award
Human Frontier Science Program Young Investigator Award
OSA BIOMED 2008 Program Chair: “Diffuse optical imaging and tomography”
Rodriguez Junior Faculty Award 2008, Columbia University School of Engineering and Applied Sciences

Grant Support

National Institute of Neurological Disorders and Stroke (NINDS) - PI (R21)
Wallace H Coulter Foundation - PI (Young Investigator)
Human Frontiers Science Program - PI (Young Investigator)
National Heart, Blood and Lung Institute (NHLBI) - subcontract Co-PI
National Institute of Biomedical Imaging and BioEngineering (NIBIB) - Phase I SBIR
National Cancer Institute (NCI) - imaging core
Mentored Students Graduate Fellowships, NSF (2), NDSEG/ONR (1)

Publications

Hillman E. M. C, PhD Thesis (2002), Download
Hillman E. M. C and Moore A, "All-optical anatomical coregistration for small animal molecular imaging using dynamic contrast", Nature Photonics, 1 (9), 526 - 530, (2007).
Hillman E. M. C, Bernus O, Pease E, Bouchard M. B. Pertsov A. “Depth-resolved optical imaging of transmural electrical propagation in perfused heart”, Optics Express, 15 (26), 17827-17841, (2007).
Hillman E. M. C, "Optical Brain Imaging In-vivo: Techniques and Applications from Animal to Man" [Invited Review], J Biomed Opt, 12(5), 051402 (2007). *Also selected to appear in the “Virtual Journal of Biological Physics Research”
Hillman E. M. C, Devor A, Bouchard M. B, Dunn A. K, Krauss G. W, Skoch J, Bacskai B. J, Dale A. M, Boas D. A, “Depth-resolved Optical Imaging and Microscopy of Vascular C ompartment Dynamics During Somatosensory Stimulation”, NeuroImage, 35(1): 89-104 (2007) '>Supplementary Data.
Devor A, Tian P, Nishimura N, Teng IC, Hillman E. M. C, Narayanan S. N, Ulbert I, Boas D. A, Kleinfeld D, Dale A. M.“Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative BOLD”, J Neurosci, 27(16): 4452-4459. (2007)Supplementary Data
Custo A, Wells W. M, Barnett A. H, Hillman E. M. C, Boas D. A,"Effective Scattering Coefficient of the Cerebral Spinal Fluid in Adult Head Models for Diffuse O ptical Imaging", Appl Opt. 45(19): 4747-4755 (2006).
Zhang Q, Brukilacchio T. J, Li A, Stott J. J, Chaves T, Hillman E. M. C, Wu T, Chorlton M. A, Rafferty E, Moore R. H, Kopans D. B, Boas D. A., "Co-registere d Tomographic X-ray and Optical Breast Imaging: Initial Results." J Biomed Opt, 10(2), 024033-1-9 (2005).
Corlu A, Choe R, Durduran T, Lee K, Schweiger M, Arridge S. R, Hillman E. M. C, Yodh A. G., "Diffuse optical tomography with spectral constraints and wavelength opt imization." Appl Opt, 44(11), 2082-2093 (2005)
Li A, Boverman G, Zhang Y, Brooks D, Miller E. L, Kilmer M. E, Zhang Q, Hillman E. M. C, Boas D. A., "An optimal linear inverse solution given multiple priors in diffuse optical tomography." Appl Opt, 44(10), 1948-1956 (2005)
Hillman, E. M. C, Boas, D. A, Dale, A. M, Dunn, A. K, "Laminar Optical Tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media" Optics Letters, 29, (14), 1650-1652 (2004).
Hillman, E. M. C, "Optical tomography", Book chapter in 'Optics Encyclopedia', Wiley-VCH. (Released December 2003).
Corlu, A, Durduran, T, Choe, R, Schweiger, M, Hillman, E. M. C, Arridge, S. R. Yodh, A. G,>"Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography” Optics Letters, 28, 23, 2339-2341 (2003).
Hebden, J. C, Gonzalez, F. M, Gibson, A, Hillman, E. M. C, Yusof, R, Everdell, N, Delpy, D. T, Zaccanti, G, and Martelli, F, “Assessment of an in situ temporal calibra tion method for time-resolved optical tomography” Journal of Biomedical Optics 8, 87-92 (2003).
Hebden,J. C, Gibson, A, Yusof, R, Everdell, N, Hillman, E. M. C, Delpy, D. T, Arridge, S. R, Austin, T, Meek, J. H, Wyatt, J. S, "Three-dimensional optical tomography of the premature infant brain” Phys. Med. Biol , 47, 23, 4155-4166 (2002).
Hebden, J. C, Veenstra, H, Dehghani, H, Hillman, E. M. C, Schweiger, M, Arridge, S. R, nd Delpy, D. T , '>"Three dimensional time-resolved optical tomogr aphy of a conical breast phantom" Applied Optics 40 19, 3278-3287 (2001).
Hillman, E. M. C, Hebden, J. C, Schweiger, M, Dehghani, H, Schmidt, F. E. W, Delpy, D. T, Arridge, S. R "Time Resolved Optical Tomography of the Human Forearm&qu ot; Phys. Med. Biol, 46, 4, 1117-1130 (2001)
Hillman,E.M.C, Hebden,J.C, Schmidt,F.E.W, Arridge,S.R, Schweiger,M, Dehghani,H, Delpy, D.T '>"Calibration techniques and datatype extraction for time-resolved op tical tomography" Rev Sci Instrum, 71, 9, 3415-3427 (2000).
Schmidt, F. E. W, Hebden, J. C, Hillman, E. M. C, Fry ,M. E, Schweiger,M, Delpy,D. T "Multiple slice imaging of a tissue-equivalent phantom using time-resolved op tical tomography" Applied Optics 39, 19 3380-3387 (2000).
Arridge, S. R., Hebden, J. C, Schweiger, M, Schmidt, FEW, Fry, M. E. Hillman, E. M. C, Dehghani,H "A method for 3D time-resolved optical tomography&q uot;"A method for 3D time-resolved optical tomography" Imaging. Syst. Technol, 11, 2-11 (2000).
Schmidt, F.E.W, Fry, M.E, Hillman, E.M.C, Hebden, J.C, and Delpy, D.T "A 32-channel time-resolved instrument for medical optical tomography" R ev. Sci. Instrum 71, 1, 256 - 265 (2000).
Hebden, J.C, Schmidt, F.E.W, Fry, M.E, Schweiger, M, Hillman, E.M.C, Delpy, D.T, and Arridge, S. R "Simultaneous reconstruction of absorption and scatter ing images using multi-channel measurement of purely temporal data" Optics Letters, 24, 8, 534-536. (1999)
Elwell, C.E, Springett, R, Hillman, E.M.C, Delpy,D.T "Oscillations in Cerebral Haemodynamics - Implications for Functional Activation Studies". &q uot;Oscillations in Cerebral Haemodynamics - Implications for Functional Activation Studies" Adv. Exp Med & Biol 471, 57-65 (1999).