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Journal papers:
Burgess S. A, Bouchard M. B, Yuan B, Hillman E. M. C. “Simultaneous Multi-Wavelength Laminar Optical Tomography”, Optics Letters, in press (2008).
Hillman E.M.C, Burgess S.A. “Sub-millimeter 3D Optical Imaging of Living Tissue using Laminar Optical Tomography”, Laser & Photonics Reviews, in press (2008).
Radosevich A. J, Bouchard M. B, Burgess S. A, Chen B. R, Hillman E. M. C. “Hyper-spectral in-vivo two-photon microscopy of intrinsic fluorophores”, Optics Letters, 33 (18), 2164-2166, (2008).
Hillman E. M. C, Burgess S. A, Chen B. “Macroscopic molecular optical imaging of rodent brain”, Book Chapter in ‘Molecular Imaging of the Rodent Brain’ (Neuromethods Series), Editor. Bacskai B. J, Ed. In press 2008, Human Press (Springer).
Hillman E. M. C, Bernus O, Pease E, Bouchard M. B. Pertsov A. “Depth-resolved optical imaging of transmural electrical propagation in perfused heart”, Optics Express, 15 (26), 17827-17841, 2007.
Hillman E. M. C and Moore A. "All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast", Nature Photonics, 1 (9), 526 - 530, 2007.
Hillman E. M. C, “Optical Brain Imaging In-vivo: Techniques and Applications from Animal to Man” [Invited Review] J Biomed Opt, 12(5), 051402 (2007). *Also selected to appear in the “Virtual Journal of Biological Physics Research”
Hillman E. M. C, Devor A, Bouchard M. B, Dunn A. K, Krauss GW, Skoch J, Bacskai J, Dale A. M, Boas D. A. “Depth-resolved Optical Imaging and Microscopy of Vascular Compartment Dynamics During Somatosensory Stimulation”, NeuroImage, 35(1): 89-104 (2007) Supplementary Data
Devor A, Tian P, Nishimura N, Teng IC, Hillman E. M. C, Narayanan S. N, Ulbert I, Boas D. A, Kleinfeld D, Dale A. M. “Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative BOLD”, J Neurosci, 27(16): 4452-4459. (2007) Supplementary Data
Custo A, Wells W. M, Barnett A. H, Hillman E. M. C, Boas D. A, "Effective Scattering Coefficient of the Cerebral Spinal Fluid in Adult Head Models for Diffuse Optical Imaging", Appl Opt. 45(19): 4747-4755 (2006).
Zhang Q, Brukilacchio T. J, Li A, Stott J. J, Chaves T, Hillman E. M. C, Wu T, Chorlton M. A, Rafferty E, Moore R. H, Kopans D. B, Boas D. A, "Co-registered Tomographic X-ray and Optical Breast Imaging: Initial Results.", J Biomed Opt, 10(2), 024033-1-9 (2005).
Corlu A, Choe R, Durduran T, Lee K, Schweiger M, Arridge S. R, Hillman E. M. C, Yodh A. G, "Diffuse optical tomography with spectral constraints and wavelength optimization.", Appl Opt, 44(11), 2082-2093 (2005)
Li A, Boverman G, Zhang Y, Brooks D, Miller E. L, Kilmer M. E, Zhang Q, Hillman E. M. C, Boas D. A, "An optimal linear inverse solution given multiple priors in diffuse optical tomography.", Appl Opt, 44(10), 1948-1956 (2005)
Hillman, E. M. C, Boas, D. A, Dale, A. M, Dunn, A. K, "Laminar Optical Tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media", Optics Letters, 29, (14), 1650-1652 (2004).
Hillman, E. M. C, “Optical tomography”, Book chapter in 'Optics Encyclopedia', Wiley-VCH. (Released December 2003).
Corlu, A, Durduran, T, Choe, R, Schweiger, M, Hillman, E. M. C, Arridge, S. R. Yodh, A. G, "Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography”: Optics Letters, 28, 23, 2339-2341 (2003).
Hebden, J. C, Gonzalez, F. M, Gibson, A, Hillman, E. M. C, Yusof, R, Everdell, N, Delpy, D. T, Zaccanti, G, and Martelli, F, “Assessment of an in situ temporal calibration method for time-resolved optical tomography”: Journal of Biomedical Optics 8, 87-92 (2003).
Hebden,J. C, Gibson, A, Yusof, R, Everdell, N, Hillman, E. M. C, Delpy, D. T, Arridge, S. R, Austin, T, Meek, J. H, Wyatt, J. S, "Three-dimensional optical tomography of the premature infant brain”, Phys. Med. Biol , 47, 23, 4155-4166 (2002).
Hebden, J. C, Veenstra, H, Dehghani, H, Hillman, E. M. C, Schweiger, M, Arridge, S. R, and Delpy, D. T , "Three dimensional time-resolved optical tomography of a conical breast phantom", Applied Optics 40 19, 3278-3287 (2001).
Hillman, E. M. C, Hebden, J. C, Schweiger, M, Dehghani, H, Schmidt, F. E. W, Delpy, D. T, Arridge, S. R "Time Resolved Optical Tomography of the Human Forearm", Phys. Med. Biol, 46, 4, 1117-1130 (2001)
Hillman,E.M.C, Hebden,J.C, Schmidt,F.E.W, Arridge,S.R, Schweiger,M, Dehghani,H, Delpy, D.T "Calibration techniques and datatype extraction for time-resolved optical tomography", Rev Sci Instrum, 71, 9, 3415-3427 (2000).
Schmidt, F. E. W, Hebden, J. C, Hillman, E. M. C, Fry ,M. E, Schweiger,M, Delpy,D. T "Multiple slice imaging of a tissue-equivalent phantom using time-resolved optical tomography", Applied Optics 39, 19 3380-3387 (2000).
Arridge, S. R, Hebden, J. C, Schweiger, M, Schmidt, FEW, Fry, M. E. Hillman, E. M. C, Dehghani, H "A method for 3D time-resolved optical tomography". J. Imaging. Syst. Technol, 11, 2-11 (2000).
Schmidt, F.E.W, Fry, M.E, Hillman, E.M.C, Hebden, J.C, and Delpy, D.T "A 32-channel time-resolved instrument for medical optical tomography", Rev. Sci. Instrum 71, 1, 256 - 265 (2000).
Hebden, J.C, Schmidt, F.E.W, Fry, M.E, Schweiger, M, Hillman, E.M.C, Delpy, D.T, and Arridge, S. R "Simultaneous reconstruction of absorption and scattering images using multi-channel measurement of purely temporal data", Optics Letters, 24, 8, 534-536. (1999)
Elwell, C.E, Springett, R, Hillman, E.M.C, Delpy,D.T "Oscillations in Cerebral Haemodynamics - Implications for Functional Activation Studies". Adv. Exp med & Biol 471, 57-65 (1998).
Proceedings (selected):
Bouchard M. B, Burgess S. A, Moussazadeh P, Radosevich AJ, Wuskell JP, Loew LM, Pertsov A, Hillman E. M. C. Electrical and metabolic imaging of cardiac ischemia In: OSA Biomedical Topical Meetings, OSA Technical Digest, Optical Society of America, Washington DC, 2008. March 16-19; St Petersberg FL.
Yuan B, Hillman E. M. C. Feasibility of 3-D Frequency-Domain Fluorescence Lifetime Imaging based on Laminar Optical Tomography. In: OSA Biomedical Topical Meetings, OSA Technical Digest, Optical Society of America, Washington DC, 2008. March 16-19; St Petersberg FL.
Radosevich AJ, Bouchard M. B, Burgess S. A, Stolper R, Chen B, Hillman E. M. C. Hyperspectral in-vivo two-photon microscopy. In: OSA Biomedical Topical Meetings, OSA Technical Digest, Optical Society of America, Washington DC, 2008. March 16-19; St Petersberg FL.
Burgess S. A, Yuan B, Bouchard M. B, Ratner D, Hillman E. M. C. Simultaneous Multi-Wavelength Laminar Optical Tomography Imaging of Skin Cancer. In: OSA Biomedical Topical Meetings, OSA Technical Digest, Optical Society of America, Washington DC, 2008. March 16-19; St Petersberg FL.
Iranmahboob AK, Hillman E. M. C. Diffusion vs. Monte Carlo for Image Reconstruction in Mesoscopic Volumes. In: OSA Biomedical Topical Meetings, OSA Technical Digest, Optical Society of America, Washington DC, 2008. March 16-19; St Petersberg FL.
Hillman E. M. C, Chen B, Burgess S. A, Radosevich A. J, Bouchard M. B, Iranmahboob AK, Das A, Cauli B. Multidimensional functional optical imaging of the brain. [Invited] In: OSA Biomedical Topical Meetings, OSA Technical Digest, Optical Society of America, Washington DC, 2008. March 16-19; St Petersberg FL.
Hillman E. M. C, Bouchard M. B, Burgess S. A, Gossage K, Mansfield JR, Levenson RM, Dynamic Molecular Imaging: Anatomical Co-registration and Dynamic Contrast Enhancement. In: OSA Biomedical Topical Meetings, OSA Technical Digest, Optical Society of America, Washington DC, 2008. March 16-19; St Petersberg FL.
Hillman E. M. C, Yuan B, Burgess S. A, Iranmahboob AK, Bouchard M. B. Depth-resolved optical imaging of calcium sensitive dyes in somatosensory cortex in-vivo, Society for Neuroscience 2007. November 3-7; San Diego CA.
Hillman E. M. C, Levenson RM. All-Optical Small Animal Anatomical Co-registration using Dynamic Contrast Enhancement (DyCE), AMI/SMI Joint Molecular Imaging Conference (paper highlighted as top 25 out of >900 abstracts), 2007, September 7-11; Providence RI.
Burgess S. A, Yuan B, Radosevich A. J, Bouchard M. B, Hillman E. M. C. “High-resolution 3D optical imaging of tissue” [Invited], IEEE Proceedings LEOS (2007).
Burgess S. A, Yuan B, Pease E, Iranmahboob A, Hillman E. M. C. “Laminar Optical Tomography for Dermal and Cardiac Imaging”. Engineering Conferences International: Advances in Optics for Biotechnology, Medicine and Surgery, Naples, June 2007.
Hillman E. M. C “High resolution functional optical imaging of rodent cortex: investigating mechanisms of functional activation” [Invited, (Optics in Neuroscience)] at ‘Optical Diagnostic Imaging from Bench to Bedside’ Technical Workshop at the National Institutes of Health, NIH Bethesda, MD 2006.
Hillman E. M. C, Bouchard M, Devor A, De Crespigny A, Boas D. A. “Functional optical imaging of brain activation: a multi-scale, multi-modality approach” [Invited] IEEE Proceedings of the Life Science Systems and Application Workshop, Bethesda MD, July 2006.
Hillman E. M. C. “High resolution functional optical imaging of exposed cortex in-vivo” [Invited, (Imaging Brain Function and Disease)] at Gordon Research Conference: Lasers in Medicine and Biology, Holderness, NH (2006).
Hillman E. M. C, Devor A, Boas DA “High-resolution functional optical imaging of living tissues“ [Invited] In: IEEE International Symposium of Biomedical Imaging Medical Imaging (ISBI) Arlington, VA (2006)
Bouchard M, Ruvinskaya S, Boas DA and Hillman E. M. C. “Video-rate two-photon microscopy of cortical hemodynamics in-vivo“ In: OSA Biomedical Topical Meetings, OSA Technical Digest, Fort Lauderdale, FL (2006)
Hillman E. M. C, Bouchard M, Devor A, de Crespigny A, Boas D. A “High-resolution functional optical imaging: sub-millimeter physiology of living tissue“ [Invited] In: OSA Biomedical Topical Meetings, OSA Technical Digest, Fort Lauderdale, FL (2006)
Hillman E. M. C, Devor A, Dunn A. K, Boas D. A “Laminar Optical Tomography: High-resolution 3D functional imaging of superficial tissues“ [Invited] In: Medical Imaging, SPIE, San Diego, CA (2006)
Hillman E. M. C, Devor A, Dunn A. K, Skoch J, Bacskai B. J, Dale A. M, Boas D. A. “Resolving the roles of vascular compartments during functional activation: A high-resolution 3D optical imaging study“ In: Society for Neuroscience Conference proceedings, Washington DC (2005)
Hillman E. M. C, Devor A, Dale A. M, Dunn A. K, Boas D. A “The use of depth-resolved optical imaging to separate cortical vascular compartments during functional activation“ In: Brain05, International Society for Cerebral Blood Flow and Metabolism, Amsterdam, Netherlands (2005)
Selb J. J, Hillman E. M. C, Joseph D. K, Boas D. A “Discrimination between superficial and cerebral signals during functional brain imaging with a time-gated system”: in OSA European Conference on Biomedical Optics Technical Digest, Munich Germany (2005)
Hillman E. M. C, Devor, A, Dunn A. K, Boas D. A “3D high-resolution optical imaging of cortical activation: Vascular compartment separation using spatio-temporal constraints and priors” [Invited]: in OSA European Conference on Biomedical Optics Technical Digest, Munich Germany (2005)
Hillman, E. M. C, Dunn, A. K, Boas, D. A, “Laminar Optical Tomography of Cortical Activation: resolving depth-dependent hemodynamics from 0 to 2mm”: in Biomedical Tops, OSA Tech Digest (2004).
Hillman, E. M. C, Arridge,S. R, Hebden, J. C, Delpy, D. T, "Oxygen saturation and blood-volume derivation from multi-wavelength time-resolved optical tomography data”: in Biomedical Tops, OSA Tech Digest. 599-601 (2002).
Hebden J. C, Hillman E. M. C, Gibson A, Everdell N, Yusof R, Md, Delpy D. T, Arridge S. R, Austin T, Meek J. H, "Time resolved optical imaging of the newborn infant brain: Initial clinical results”: in Biomedical Tops, OSA Tech Digest. 587-589 (2002).
Hebden J. C, Bland, T, Hillman E. M. C, Gibson A, Everdell N, Delpy D. T, Arridge S. R, " Optical tomography of the breast using a 32-channel time-resolved imager”: in Biomedical Tops, OSA Tech Digest. 187-189 (2002).
Gibson A, Dehghani H, Yusof R, Md, Hillman E. M. C, Hebden J. C, Schweiger M, Arridge S. R, Delpy D. T "Optical tomography of a realistic head-shaped phantom”: in Biomedical Tops, OSA Tech Digest. 623-625 (2002).
Riley J. D, Arridge S. R, Chrysanthou Y, Dehgahani H, Hillman E. M. C, Schweiger M, "The Radiosity Diffusion Model in 3D", SPIE Proc 4431, (2001).
Hillman E. M. C, Dehghani H, Hebden J. C, Arridge S. R, Schweiger M, Delpy D. T "Differential imaging in heterogeneous media: limitations of linearization assumptions in optical tomography". Proc SPIE 4250, 327-338 (2001)
Dehghani H, Hillman E. M. C, Schweiger M, Arridge S. R, and Delpy D. T, "Optical tomography of a 3D multilayered head model", Proc SPIE 4250, 45-52. (2001).
Hebden J. C, Schmidt F. E. W, Hillman E. M. C, Arridge S. R, Schweiger M, and Delpy D. T "Optical tomography of the human forearm", Proceedings of the Inter-Institute Workshop on In Vivo Optical Imaging at the NIH, ed. A. H. Gandjbakhche (OSA, Washington DC, 2000) pp. 167-171.
Hillman E.M.C, Hebden J.C, Schmidt F.E.W, Arridge S.R , Fry M.E, Schweiger M, Delpy D.T "Initial Clinical testing of the UCL 32 channel time-resolved instrument for optical tomography", in Biomedical Tops, OSA Tech Digest. 100-102 (2000)
Theses:
Hillman E. M. C. “Experimental and theoretical investigations of near infrared tomographic imaging methods and clinical applications” (30Mb) [Doctoral thesis]. London UK, University of London: 2002
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