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Summary
This project uses Laminar Optical Tomography (LOT), a technique originally developed for depth-resolved optical brain imaging (see here).
The aim of this project is to apply LOT to the clinical problem of margin mapping and invasion-depth determination for skin cancer surgical planning. Specifically we are working to develop a system capable of imaging the low contrast, subsurface margins of Lentigo Maligna lesions by using the depth-resolved optical imaging capabilities of LOT. Lentigo Maligna often occurs as a result of prolonged sun exposure, and is commonly found on the face and neck. Since it is difficult to determine the margins by eye, surgeons must base their excision on estimated boundaries of between 0.5 and 1cm around the visible tumor. On the face and neck, it can be very challenging to preserve important facial features. The current standard of care is to remove the lesion and then use histology to determine whether the tumor margins have been cleared, and also to determine the invasion depth of the tumor and therefore the likelihood of metastasis. In some cases it is necessary to repeat surgery to clear additional margins after histological analysis.
We hope that LOT can provide a new tool to aid surgeons in pre-surgical planning of excision boundaries. We hope that a measure of invasion depth and tumor function may also provide expedited assessment of the likelihood of metastasis to allow improved planning of any necessary systemic treatments.
Funding
Wallace Coulter Foundation Early Career Award (Hillman)
Collaborators
Dr Desiree Ratner MD, Associate Clinical Professor of Dermatology, Columbia University College of Physicians and Surgeons
Results and Publications
Burgess S. A, Bouchard M. B, Yuan B, Hillman E. M. C. “Simultaneous Multi-Wavelength Laminar Optical Tomography”, Optics Letters, in press (2008).
Burgess S. A, Yuan B, Bouchard M. B, Ratner D, Hillman E. M. C. Simultaneous Multi-Wavelength Laminar Optical Tomography Imaging of Skin Cancer. In: OSA Biomedical Topical Meetings, OSA Technical Digest, Optical Society of America, Washington DC, 2008. March 16-19; St Petersberg FL.
Burgess S. A, Yuan B, Pease E, Iranmahboob A, Hillman E. M. C. Laminar Optical Tomography for Dermal and Cardiac Imaging. Engineering Conferences International: Advances in Optics for Biotechnology, Medicine and Surgery, Naples, June 2007.
Hillman E. M. C, Devor A, Dunn AK, Boas DA “Laminar Optical Tomography: High-resolution 3D functional imaging of superficial tissues“ [Invited] In: Medical Imaging, SPIE, San Diego, CA (2006)
Hillman E. M. C, Devor A, Boas DA “High-resolution functional optical imaging of living tissues“ [Invited] In: IEEE International Symposium of Biomedical Imaging Medical Imaging (ISBI) Arlington, VA (2006)
Hillman, E. M. C, Boas, D. A, Dale, A. M, Dunn, A. K, "Laminar Optical Tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media", Optics Letters, 29, (14), 1650-1652 (2004).
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