Microscale Biocomplexity Laboratory

tribilayer
Alignment and patterning of three different supported lipid bilayers on a single surface
threecomponent
Micropatterned, multicomponent surfaces provide control over the layout of neurons in culture
multicomponent
Micropatterned surface targeting T Cell Receptor (red) and CD28 (green).
lab1
cellcluster
Cells are complex yet elegant microscale machines. Contemporary surface engineering approaches allow us to talk with cells at the appropriate scales, first learning the rules that govern their function and later controlling this behavior to promote a desired response.
lab3
FNECad
Micropatterned surfaces allow the study of crosstalk between integrin (grey dots) and cadherin (surrounding areas) signaling. Integrin signaling inhibits cadherin response in MCF-7 (left) but not MDCK (right) cells.
lab2
trelec
Electrophoresis of charged, fluorescently-labeled lipids in a supported bilayer that is partitioned into an array by grids of fibronectin.

Cells have the remarkable ability to recognize the microscale details of their extracellular envicornment. Our laboratory focuses on understanding cells and cell signaling at the micro- and nano-scale using contemporary surface engineering techniques. We are currently looking for creative and innovative individuals at multiple levels. These projects offer experience with microfabrication, immunology, cell signaling, and biophysics. Please send current CV/resume to Prof. Kam.