BME Seminar: David Umulis, Ph.D., Purdue University
On Friday, March 24, 2023, we are excited to welcome Prof. David Umulis from Purdue University as he presents "Delineating mechanisms of BMP-mediated patterning in embryo and cochlear development."
ABOUT THE SEMINAR
Delineating mechanisms of BMP-mediated patterning in embryo and cochlear development
Bone Morphogenetic Proteins regulate spatial patterning and differentiation in many stages of development and in many tissue types and organisms. We quantified BMP signaling activity in dorsal/ventral (DV) axis patterning in zebrafish embryos and in the developing mouse inner ear organ of corti. We developed AI tools to segment every cell in the developing tissues and used the data to build and test simulations of the developing structures. Through this we identified that a source-sink mechanism of BMP patterning is consistent with both zebrafish embryonic development and in the developing organ of corti in mouse. Furthermore, we found that the BMP gradient forms an information-maximizing linear profile sufficient for multiple boundary specification along the developing organ of corti needed for precise hair cell placement. These systems highlight how the back-and-forth between experiment and simulation drives an integrative understanding of developmental systems, which is the foundation of the new NSF EMBRIO Institute.
ABOUT THE SPEAKER
David Umulis, Ph.D., Dane A. Miller Head, Professor of the Weldon School of Biomedical Engineering, Purdue University
Dr. David M. Umulis is the Dane A. Miller Head and Professor of the Weldon School of Biomedical Engineering at Purdue University and Director of the NSF-funded EMBRIO Institute. Umulis leads the Weldon School to advance discovery and translation in biomedical imaging, neuroengineering, instrumentation, computational biomedicine, and engineered biomaterials. The NSF EMBRIO Institute uses engineering, imaging, AI and organismal biology to uncover mechanisms of wound healing and cellular defense. Umulis is a member of the Purdue Teaching Academy, and he has received 2011 Richard L. Kohls Early Career Award and the 2021 Henry T. Yang Award for Leadership in Service.
ABOUT THE 2022-2023 BME SEMINAR SERIES
The Department of Biomedical Engineering at Columbia University is proud to host an annual weekly seminar series on the latest developments and research in Biomedical Engineering. The weekly series takes place on Friday mornings at 11:00 AM Eastern and includes a variety of renowned academics from top universities to talk about their specific research and experience. The January 21 seminar is a virtual event.
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