On Friday, March 11th @ 11:00AM ET, we welcome Prof. Jude Phillip from Johns Hopkins University as he presents, "Ageing at single-cell resolution."

ABOUT THE SEMINAR

Ageing at single-cell resolution

Ageing is inevitable, and while we gain one chronological year with the passing of each birthday, the biological outlook among individuals is quite variable. A growing body of evidence shows that the interactions of intrinsic and extrinsic factors, across length scales from molecules to organisms, contribute to the rates of ageing and age-associated diseases in humans. However, it is unclear how underlying molecular states of an individual relate to their clinical outlook. We postulate that studying age-associated changes at intermediate length scales of cells may provide a key link to understand ageing patterns. As integrators of molecular signals, cells offer a sensitive meso-scale view of ageing, with cellular dysfunctions likely occurring prior to the manifestation of age-associated diseases. In the seminar, I will present: how biophysical properties of cells constitute a framework to study ageing, the role of cellular heterogeneity in propagating ageing phenotypes, and a generalizable framework to understand emergent patterns of single-cell motility with applications for healthy ageing and disease.

ABOUT THE SPEAKER

Jude Phillip, Ph.D., Assistant Professor of Biomedical Engineering, Chemical and Biomolecular Engineering, and Oncology; Core Member, Institute for Nanobiotechnology (INBT), Johns Hopkins University

Jude Phillip is an Assistant Professor of Biomedical Engineering, with secondary appointments in Chemical and Biomolecular Engineering, Oncology, and is a core member in the Institute for Nanobiotechnology (INBT) at Johns Hopkins University. He completed his B.Eng. in Chemical Engineering at CCNY, a PhD in Chemical and Biomolecular Engineering at Johns Hopkins University, and postdoctoral training at Weill Cornell Medicine. At Johns Hopkins his lab studies biological ageing dynamics in health and disease. He combines fundamental engineering approaches with ageing and oncology research to develop translatable strategies and technologies to probe ageing and disease.

ABOUT THE 2021-2022 BME SEMINAR SERIES

The Department of Biomedical Engineering at Columbia University is proud to host an annual weekly seminar series on the latest developments and research in Biomedical Engineering. The weekly series takes place on Friday mornings at 11:00AM Eastern and includes a variety of renowned academics from top universities to talk about their specific research and experience. This is a hybrid event.