BME Seminar Series - Kun Zhang, University of California, San Diego
Friday,
March 22, 2019
11:00 AM - 12:00 PM
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TwitterConstruction of 3D single-cell maps of human organs.
Abstract:
Detailed characterization of the cell types comprising the highly complex
human organs is essential to understanding their functions. Such tasks require highly
scalable experimental approaches to examine different aspects of the molecular state of
individual cells, registering cells to 3D coordinates, as well as the computational
integration to produce unified cell state annotations. To this end, we have established
experimental platforms and computational pipelines for constructing 3D single-cell maps
for human adult organs. In this talk I will present our recent results on the creation of a
integrative single-cell transcriptome and chromatin accessibility maps of selected human
brain regions, and discuss our on-going efforts for building whole-organ maps for human
brain, lung and kidney.
Abstract:
Detailed characterization of the cell types comprising the highly complex
human organs is essential to understanding their functions. Such tasks require highly
scalable experimental approaches to examine different aspects of the molecular state of
individual cells, registering cells to 3D coordinates, as well as the computational
integration to produce unified cell state annotations. To this end, we have established
experimental platforms and computational pipelines for constructing 3D single-cell maps
for human adult organs. In this talk I will present our recent results on the creation of a
integrative single-cell transcriptome and chromatin accessibility maps of selected human
brain regions, and discuss our on-going efforts for building whole-organ maps for human
brain, lung and kidney.
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