Tal Danino

• Associate Professor (tenured), Biomedical Engineering, Columbia Engineering, 2023 – present
• Associate Professor (tenure track), Biomedical Engineering, Columbia Engineering, 2020 – 2023
• Assistant Professor, Biomedical Engineering, Columbia Engineering, 2016 – 2020

• Member, Data Science Institute, Columbia University, 2016 - present 

• Member, Herbert Irving Comprehensive Cancer Center, Columbia University, 2016 - present 


• 2020 Cancer Research Institute (CRI) Lloyd J. Old Scientist’s Taking Risks (STAR) Award

• 2020 Pershing Square Sohn Prize for Young Investigators in Cancer Research

• 2019 NSF CAREER Award
• 2018 ALCF Young Innovators Team Award (YITA)

• 2017 Breast Cancer Research Foundation-AACR Career Development Award
• 2017 Department of Defense Era of Hope Breast Cancer Scholar Award

• 2015 NIH Pathway to Independence Award (K99/R00)

• 2015 TED Fellow

• 2014 New England Biolabs Passion in Science Award
• 2012 NIH Ruth L. Kirschstein National Research Service Award (NRSA)
• 
2011 Misrock Postdoctoral Fellowship
• 
2006 Department of Energy Computational Science Graduate Fellowship (DoE CSGF)
• 
2002 Arthur Beckman Undergraduate Research Scholar
• 
2001 California Governor’s Math and Science Scholar

∗ indicates corresponding senior author(s). ‡ equal contribution.

Peer-Reviewed Publications

• Vincent, R.L.*, Gurbatri, C.R.*, Li, F., Vardoshvili, A., Coker, C., Im, J., Ballister, E.R., Rouanne, M., Savage, T., de los Santos-Alexis, K., Redenti, A., Brockmann, L., Komaranchath, M., Arpaia, N., Danino, T. Probiotic-guided CAR-T cells for solid tumor targeting Science 382(6667), 211-218 (2023)
• Hahn, J., Ding, S., Im, J., Harimoto, T., Leong, K.W., Danino, T.  Bacterial therapies at the interface of synthetic biology and nanomedicine Nature Reviews Bioengineering (2023). doi 10.1038/s44222-023-00119-4
• Doshi, A., Shaw, M., Tonea, R., Moon, S., Minyety, R., Doshi, A., Laine, A., Guo, J., Danino, T. Engineered bacterial swarm patterns as spatial records of environmental inputs
  Nature Chemical Biology 19(7), 878–886 (2023)
• Serebrinsky-Duek, K., Barra, M., Danino, T., Garrido, D. Engineered bacteria for short-chain-fatty-acid repressed expression of biotherapeutic molecules. Microbiology Spectrum 11:2 (2023)
• Savage, T., Vincent, R., Hanrahan, S., Huang, L., Ahn, A., Pu, K., Li, F., Coker, C., Danino, T., Arpaia, N. Chemokines expressed by engineered bacteria recruit and orchestrate antitumor immunity. Science Advances 9:10 (2023)
• Deb, D., Wu, Y., Coker, C., Harimoto, T., Huang, R., Danino, T.∗ Design of combination therapy for engineered bacterial therapeutics in non-small cell lung cancer.Scientific Reports 12:21551 (2022)
• Gurbatri, C., Arpaia, N., Danino, T.∗ Engineering bacteria as interactive cancer therapies.Science 378(6622), 858-864 (2022)
• Harimoto, T.‡, Hahn, J.‡, Chen, Y., Im, J., Zhang, J., Hou, N., Coker, C., Gray, K., Harr, N., Chowdhury, S., Pu, K., Nimura, C., Arapaia, N., Leong, K.∗, Danino, T.∗ A programmable encapsulation system improves delivery of therapeutic bacteria in mice. Nature Biotechnology 40,1259–1269 (2022)
• Deb, D.‡, Zhu, S.‡, LeBlanc, M., Danino, T.∗ Assessing chemotherapy dosing strategies in a spatial cell culture model. Frontiers in Oncology 24 (2022)
• Doshi, A.‡, Shaw, M.‡, Tonea, R., Minety, R., Moon, S., Laine, A., Guo, J.∗, Danino, T.∗ A deep learning pipeline for segmentation of Proteus mirabilis colony patterns. IEEE 19th International Symposium on Biomedical Imaging (ISBI) 1-5 (2022)
• Zhu, N.‡, Liu, C.‡, Singer, Z., Danino, T., Laine, A., Guo, J. Segmentation with residual attention U-Net and an edge-enhancement approach preserves cell shape features. IEEE Engineering in Medicine and Biology Society (EMBC) (2022)
• Harimoto, T., Deb, D., Danino, T.∗ A rapid screening platform to coculture bacteria within tumor spheroids. Nature Protocols (2022)
• Kobayashi, H., Gieniec, K.A., Lannagan, T.R.M, Wang, T., Asai, N., Mizutani, Y., Iida, T., Ando, R., Thomas, E.M., Sakai, A., Suzuki, N., Ichinose, M., Wright, J.A., Vrbanac, L., Ng, J.Q., Goyne, J., Radford, G., Lawrence, M.J., Sammour, T., Hayakawa, Y., Klebe, S., Shin, A.E., Asfaha, S., Bettington, M.L., Rieder, F.L., Arapaia, N., Danino, T., Butler, L.M., Burt, A.D., Leedham, S.J., Rustgi, A.K., Mukherjee, S., Takahashi, M., Wang, T.C., Enomoto, A., Woods, S.L., Worthley, D.L., The origin and contribution of cancer-associated fibroblasts in colorectal carcinogenesis. Gastroenterology 162(3), 890-906 (2021)
• Chien, T.‡, Harimoto, T.‡, Kepecs, B., Gray, K., Coker, C., Pu, K., Azad, T., Nolasco, A., Pavlicova, M., Danino, T.∗ Enhancing the tropism of bacteria via genetically programmed biosensors.Nature Biomedical Engineering 6, 94-104 (2021)
• Singer, Z., Ambrose, P., Danino, T.∗, Rice, CM.∗ Quantitative measurements of early alphaviral replication dynamics in single cells reveals the basis for superinfection exclusion. Cell Systems 12(3), 210-219 (2021)
• Chien, T., Jones, D.R., Danino, T.∗ Engineered bacterial production of volatile methyl salicylate. ACS Synthetic Biology 10(1), 204–208 (2020)
• Gurbatri, C., Lia, I.,Vincent, R., Coker, C., Castro, S., Treuting, P.M., Hinchliffe, T.H., Arpaia, N., Danino, T.∗ Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies. Science Translational Medicine 12(530), eaax0876 (2020)
• Barra, M., Danino, T., Garrido, D. Engineered Probiotics for Detection and Treatment of Inflammatory Intestinal Diseases.Frontiers in Bioengineering and Biotechnology 8, 265 (2020)
• Harimoto, T., Singer, Z., Velazquez, O., Zhang, J., Castro, S., Hinchliffe, T., Mather, W., Danino, T.∗ Rapid screening of engineered microbial therapies in a 3-D multicellular model. PNAS 116(18), 9002-9007 (2019)
• Chowdhury, S.,Castro, S., Coker, C., Hinchliffe, T.E.., Arpaia, N.∗, Danino, T.∗ Programmable bacteria induce durable tumor regression and systemic antitumor immunity. Nature Medicine 25(7), 1057–1063 (2019)
• Fedorec, A J.H., Ozdemir, T., Doshi, A., Rosa, L., Velazquez, O., Danino, T., Barnes, C P. Two new plasmid post-segregational killing mechanisms for the implementation of synthetic gene networks in E. coli. iScience 14, 323-334 (2019)
• Harimoto, T., Danino, T.∗ Engineering Bacteria For Cancer Therapy. Emerging Topics In Life Science 3(5), 623-629 (2019)
• Ozdemir, T., Fedorec, A J.H., Danino, T., Barnes, C P. Synthetic Biology and Engineered Live Biotherapeutics: Toward Increasing System Complexity. Cell Systems 7 (1), 5-16 (2018)
• Chien, T.‡, Doshi, A.‡, Danino, T.∗ Advances in bacterial cancer therapies using synthetic biology. Current Opinions in Systems Biology 5,1-8 (2017)
• Geller, L. T.‡, Barzily-Rokni, M.‡, Danino, T., Jonas, O.H., Shental, N., Nejman, D., Gavert, N., Zwang, Y., Cooper, Z., A., Shee, K., Thaiss, C., A., Reuben, A., Livny, J., Avraham, R., Frederick, D., T., Ligorio, M., Chatman, K., Johnston, S., E., Mosher, C., M., Brandis, A., Fuks, G., Gurbatri, C., Gopalakrishnan, V., Kim, M., Hurd, M., W., Katz, M., Fleming, J., Maitra, A., Smith, D., A., Skalak, M., Bu, J., Michaud, M., Trauger, S., A., Barshack, I., Golan, T., Sandbank, J., Flaherty, K., T., Mandinova, A., Garrett, W., S., Thayer, S., P., Ferrone, C., R., Huttenhower, C., Bhatia, S., N., Gevers, D., Wargo, J., A., Golub, T., R. Straussman, R. Tumor-microbiome mediated resistance to gemcitabine. Science 357 (6356), 1156-1160 (2017)
• Moon, S.‡, Fritz, I.‡, Singer, Z.‡, Danino, T.∗ Spatial Control of Bacteria Using Screen Printing. 3D Printing and Additive Manufacturing 3(4), 194-203 (2016)
• Din, M.‡, Danino, T.‡, Prindle, A., Allen, K., Skalak, M., Bhatia, S., Hasty, J. Synchronized cycles of bacterial lysis for in vivo delivery. Nature 536(7614), 81-85 (2016)
• Luna, J., Scheel, T., Danino, T., Shaw, K., Takacs, C., Mele, A., Fak, J., Nishiuchi, E., Cantanese, M., Rice, C., Darnell, R. Hepatitis C virus RNA functionally sequesters miR-122. Cell 160(6), 1099-1110 (2015)
• Danino, T.‡, Prindle, A.‡, Kwong, G., Skalak, M., Li, H., Allen, K., Hasty, J., and Bhatia, S. Programmable probiotics for cancer detection in urine. Science Translational Medicine 7, 289ra84 (2015)
• Danino, T.∗, Prindle, A.∗, Hasty, J., and Bhatia, S. Measuring growth and gene expression dynamics of tumortargeted S. typhimurium bacteria. Journal of Visualized Experiments 77, e50540 (2013)
• Danino, T., Lo, J., Prindle, A., Hasty, J., and Bhatia, S. In vivo gene expression dynamics from tumor-targeted bacteria. ACS Synthetic biology 1(10), 465-470 (2012)
• Prindle, A., Danino, T., Selimkhanov, J.S., Samayoa, P., Goldberg, A., Bhatia, S., and Hasty, J. Genetic circuits in Salmonella typhimurium. ACS Synthetic biology 1(10), 458-464 (2012)
• Cookson, N.A., Mather, W.H., Danino, T., Mondragon-Palomino, O., Williams, R. J., Tsimring, L. S., and Hasty, J. Queueing up for enzymatic processing: Correlated signaling through coupled degradation. Molecular Systems Biology 7,561 (2011)
• Prindle, A., Samayoa, P., Razinkov, I., Danino, T., Tsimring, L.S. and Hasty, J. A sensing array of radically coupled genetic biopixels. Nature 481, 39-44 (2011)
• Mondragon-Palomino, O., Danino, T., Selimkhanov, J., Tsimring, L.S., and Hasty, J. Entrainment of a population of synthetic genetic oscillators. Science 333(6047), 1315-1319 (2011)
• Boyer, D., Mather, W., Mondragon-Palomino, O., Orozco-Fuentes, S., Danino, T., Hasty, J., and Tsimring, L. Buckling instability in ordered bacterial colonies. Physical Biology 8, 026008 (2011)
• Danino, T., Volfson, D., Bhatia, S., Tsimring, L., and Hasty, J. In-silico pattern formation of vascular mesenchymal stem-cells in three-dimensions. PLoS ONE 6(5), e20182 (2011)
• Mather, W., Mondragon-Palomino, O., Danino, T., Hasty, J., and Tsimring, L.S. Streaming instability in growing cell populations. Physical Review Letters 104(20), 208101 (2010)
• Danino, T.‡, Mondragon-Palomino, O.‡, Tsimring, L., and Hasty, J. A synchronized quorum of genetic clocks. Nature 463, 326-330 (2010)

Perspectives, News, Books, and Book Chapters

• Danino, T. Beautiful Bacteria. Rizzoli [book] (2024)
• Redenti, A., Hahn, J., Danino, T.∗ Bacterial couriers as cancer vaccines.Nature Biomedical Engineering 6, 3–5 (2022)
• Deb, D., Shoreibah, S., Danino, T.∗ Reimagining cancer research with art.Nature Reviews Cancer (2022)
• Vincent, R.‡, Danino, T.∗ CAR-T cells SEAK help from enzymes.Nature Chemical Biology 18(1); 1-2 (2021)
• Schuerle, S., Danino, T. Bacteria as Living Microrobots to Fight Cancer.The Scientist (2020)
• Ruskin, E., Danino, T. Syndemic: Using game-based learning to engage students in the human microbiome. Connecting Sustainability Research and Teaching: Discourses on Justice, Inclusion, and Authenticity (2022)
• Danino, T. Microuniverse. Being Material p. 20-30 (2019)
• Gurbatri, C., Harimoto, T., Danino, T. Engineering bacterial therapeutics. Active Matter p. 70-82 (2017)